Inhibitors of the epidermal growth factor receptor (EGFR) have been approved as drugs to treat patients with non-small-cell lung cancer (NSCLC). While these medications exhibit good clinical efficacy, a lot of patients acquire treatment resistance due to T790M mutation, causing the disease to advance. Furthermore, these medicines may hit the EGFR wild-type receptor, leading to adverse effects. In this publication, we present the discovery of the medication osimertinib (AZD9291), a mutant-selective agent. The T790M resistant mutant and EGFR sensitizing (or activating, EGFRm+) mutant are both irreversibly inhibited. In addition, it possesses high selectivity to the receptor's wild-type form.

Bluetooth headphones have almost overtaken the wired headphone in the past five to ten years. This is due to the improved stability and sound quality of the Bluetooth transmission technology and the decrease in delay during the transmission. The portability of Bluetooth headphones makes them popular with people who spend time away from home and desks. This paper aims to observe and compare the noise-cancellation technology in the commonly-seen Bluetooth headphones in the market. The paper illustrates the common noise cancellation methods in section 2. Section 3 describes four common noise-canceling headphones and their noise-cancelling mechanism. The future outlook is provided in section 4 to display the current limitation of Bluetooth headphones, which mainly demonstrates the active noise-cancellation technology.

This paper presents an overview of development of multicarrier transmission and multiple access methods over the past decades. Focus shifts towards optimizing communication methods for a more expeditious, reliable, and efficient system. Several communicational techniques, including TDMA, CDMA, OFDMA, and GFDMA are discussed. With the growing trend of artificial intelligence, it can be predicted that artificial intelligence will be of great use in improving multicarrier transmission and multiple access methods.

Unveiling the truths behind biases in critical decision-making processes has been an enduring challenge in various domains. This reproduction study endeavors to shed light on two intriguing topics: potential bias against education in jury selection and nationalistic judging in the 2000 Olympic diving competition. By rigorously reproducing influential papers and employing sophisticated statistical tools like t-tests and permutation tests, we aim to contribute robust evidence to the ongoing discourse on bias. Our findings challenge prevailing theories by revealing no statistically significant evidence of biases against education in jury selection, providing invaluable insights for policy discussions. Simultaneously, our investigation into nationalistic judging uncovers the presence of bias among certain judges, highlighting the impact on highly competitive events’ outcomes. As we delve into these compelling issues, our study reinforces the critical importance of impartiality in decision-making processes, offering key contributions to the understanding of biases and their implications in various domains. Our primary purpose in this paper is to precisely test the reproducibility of the methods employed in the original influential papers. By carefully reproducing their analyses using advanced statistical techniques like t-tests and permutation tests, we find that the reproducibility of both papers is quite high.