Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Proceedings of the International Conference on Modern Medicine and Global Health (ICMMGH 2023)
Series Vol. 6 , 03 August 2023
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Access | Article
Mutated isocitrate dehydrogenase and therapeutic modalities
* Author to whom correspondence should be addressed.
Abstract
Isocitrate dehydrogenase (IDH) is crucial in the metabolism pathway that converts isocitrate to α-ketoglutarate. When isocitrate dehydrogenase is mutated, IDH produces 2-hydroxyglutarate instead of alpha-ketoglutarate. The newly formed IDH, with the ability to dysregulate the metabolic pathways of cells, can potentially lead to the development of cancer. The mutation leads to malignancies such as acute myeloid leukemia and glioma. Current treatment for IDH-related malignancies includes IDH inhibitors, epigenetic modulators, immunotherapies, and cancer vaccination. The development of a cancer vaccine requires the discovery of a suitable epitope being found. Newly developed deep learning algorithms have the ability to predict protein structures and thus have the potential to help discover suitable epitopes for cancer vaccines. This study discusses the structure of IDH and gives an overview of how mutated IDH can potentially cause malignancies. In addition, this study proposed potential approaches with deep learning to aid the investigation of preventing IDH using cancer vaccines.
Keywords
isocitrate dehydrogenase, acute myeloid leukemia, glioma, deep learning, cancer vaccine
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Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the International Conference on Modern Medicine and Global Health (ICMMGH 2023)
- ISBN (Print)
- 978-1-915371-65-2
- ISBN (Online)
- 978-1-915371-66-9
- Published Date
- 03 August 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/6/20230245
- Copyright
- © 2023 The Author(s)
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited