Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Proceedings of the International Conference on Modern Medicine and Global Health (ICMMGH 2023)
Series Vol. 6 , 03 August 2023
Open
Access | Article
Correlation and enlightenment between type 2 diabetes and aging from the perspective of oxidative stress
* Author to whom correspondence should be addressed.
Abstract
Type 2 diabetes is a very common type in diabetes, which is also called noninsulin-dependent diabetes. This paper focuses on the correlation between type 2 diabetes (T2D) and aging from the perspective of oxidative stress (OS), including the pathway that T2D produces oxidative stress and the effect that oxidative stress imposes on T2D. This paper also mentioned some specific mechanisms, like a glycolytic pathway, enhanced formation of advanced glycation end products (AGE), activation of protein kinase C (PKC), and deactivation of the insulin signaling pathway. In addition, this paper also talks about the important influence of OS in the process of aging. And, the attention was focused on the excessive ROS produced by mitochondria. On this basis, this paper sorts out the correlation between aging and T2D in OS and finds some experimental evidence, through which this paper also offers some enlightenment from the way of anti-aging to anti-diabetes.
Keywords
type 2 diabetes, aging, oxidative stress (OS), metformin
References
1. Halim, M., Halim, A., The effects of inflammation, aging and oxidative stress on the pathogenesis of diabetes mellitus (type 2 diabetes). Diabetes & metabolic syndrome, (13): 1165-1172 (2019).
2. Al-Sofiani, M. E., Ganji, S. S., Kalyani, R. R., Body composition changes in diabetes and aging. Journal of diabetes and its complications, (33): 451-459 (2019).
3. Launer, L. J., Diabetes and brain aging: epidemiologic evidence. Current Diabetes Reports, (5): 59–63 (2005).
4. Dhaliwal, R., Rosen, C. J., Type 2 Diabetes and Aging: A Not so Sweet Scenario for Bone. Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme, (48): 771-778 (2016).
5. Bigagli, E., Lodovici, M., Circulating Oxidative Stress Biomarkers in Clinical Studies on Type 2 Diabetes and Its Complications. Oxidative medicine and cellular longevity, pp.5953685 (2019).
6. Darenskaya, M. A., Kolesnikova, L. I., Kolesnikov, S. I., Oxidative Stress: Pathogenetic Role in Diabetes Mellitus and Its Complications and Therapeutic Approaches to Correction. Bulletin of experimental biology and medicine, pp.171, 179-189 (2021).
7. Giacco, F., Brownlee, M., Oxidative stress and diabetic complications. Circulation research, (107): 1058-1070 (2010).
8. Saeedi Borujeni, M. J., Esfandiary, E., Baradaran, A., Valiani, A., et al., Molecular aspects of pancreatic β-cell dysfunction: Oxidative stress, microRNA, and long noncoding RNA. Journal of cellular physiology, (234): 8411-8425 (2019).
9. Asmat, U., Abad, K., Ismail, K., Diabetes mellitus and oxidative stress-A concise review. Saudi pharmaceutical journal [J] SPJ: the official publication of the Saudi Pharmaceutical Society, (24): 547-553 (2016).
10. Bonomini, F., Rodella, L. F., Rezzani, R., Metabolic syndrome, aging and involvement of oxidative stress. Aging and disease, (6): 109-120 (2015).
11. Barja, G., The mitochondrial free radical theory of aging. Progress in molecular biology and translational science, (127): 1-27 (2014).
12. Poljsak, B., Šuput, D., Milisav, I., Achieving the balance between ROS and antioxidants: when to use the synthetic antioxidants. Oxidative medicine and cellular longevity, pp.956792 (2013).
13. Park, S. W., Goodpaster, B. H., Lee, J. S., Kuller, L. H., et al., Excessive loss of skeletal muscle mass in older adults with type 2 diabetes. Diabetes care, (32): 1993-1997 (2009).
14. Refaie, M. R., Sayed-Ahmed, N. A., Bakr, A. M., Abdel Aziz, M. Y., et al., Aging is an Inevitable Risk Factor for Insulin Resistance. Journal of Taibah University Medical Sciences, (1): 30-41 (2006).
15. Sanz-Cánovas, J., López-Sampalo, A., Cobos-Palacios, L., Ricci, M., et al., Management of Type 2 Diabetes Mellitus in Elderly Patients with Frailty and/or Sarcopenia. International journal of environmental research and public health, (2022).
16. Nieto-Martinez, R., et al. Chapter 18 - Diabetes Mellitus as a Risk Factor for Aging. Endocrinology of Aging. E. Corpas, Elsevier, (1): 577-606 (2021).
17. Panahi, Y., Khalili, N., Sahebi, E., Namazi, S., et al., Antioxidant effects of curcuminoids in patients with type 2 diabetes mellitus: a randomized controlled trial. Inflammopharmacology, (25): 25-31(2017).
18. Chen, S., Gan, D., Lin, S., Zhong, Y., et al., Metformin in aging and aging-related diseases: clinical applications and relevant mechanisms. Theranostics, (12): 2722-2740 (2022).
19. Mohammed, I., Hollenberg, M. D., Ding, H., Triggle, C. R., A Critical Review of the Evidence That Metformin Is a Putative Anti-Aging Drug That Enhances Healthspan and Extends Lifespan. Frontiers in endocrinology, (12): 718942 (2021).
20. Bonomini, F., Rodella, L. F., Rezzani, R., Metabolic syndrome, aging and involvement of oxidative stress. Aging and disease, 6, 109-120 (2015).
Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. Authors who publish this series agree to the following terms:
1. Authors retain copyright and grant the series right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this series.
2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the series's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this series.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See Open Access Instruction).
- Volume Title
- Proceedings of the International Conference on Modern Medicine and Global Health (ICMMGH 2023)
- ISBN (Print)
- 978-1-915371-65-2
- ISBN (Online)
- 978-1-915371-66-9
- Published Date
- 03 August 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/6/20230226
- Copyright
- © 2023 The Author(s)
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited