Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Proceedings of the International Conference on Modern Medicine and Global Health (ICMMGH 2023)
Series Vol. 6 , 03 August 2023
Open
Access | Article
Synthesis of dihydrolucilactaene: a newly discoveredantimalarial compound
* Author to whom correspondence should be addressed.
Abstract
The discovery of dihydrolucilactaene as a secondary metabolite in fungus Fusarium sp. RK97-94 showed a 100-fold increase in potency in antimalarial activity compared with its analogue—lucilactaene. Although dihydrolucilactaene shows a high level of antimalarial activity and had been shown to be a promising drug lead candidate for malaria treatment due to its highly selective cytotoxicity towards malaria-causing pathogens and negligible cytotoxicity towards other cells at lower concentrations, its complete biosynthesis pathway in Fusarium sp. RK97-94 is still to be determined, making mass production of the molecule via biological means less than desirable. In this work, we propose a complete chemical synthesis route for dihydrolucilactaene via a series of reactions involving commercially available reagents for the potential industrial application and mass production of dihydrolucilactaene.
Keywords
antimalarial activity, cyclic amide, dihydrolucilactaene, lucilactaene, synthetic pathway
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Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the International Conference on Modern Medicine and Global Health (ICMMGH 2023)
- ISBN (Print)
- 978-1-915371-65-2
- ISBN (Online)
- 978-1-915371-66-9
- Published Date
- 03 August 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/6/20230292
- Copyright
- © 2023 The Author(s)
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited