Theoretical and Natural Science

- The Open Access Proceedings Series for Conferences

Proceedings of the International Conference on Modern Medicine and Global Health (ICMMGH 2023)

Series Vol. 6 , 03 August 2023

Open Access | Article

The role and mechanism of adipose stem cells in facial anti-aging

Jiuhong Wang * 1
1 Sanya of University

* Author to whom correspondence should be addressed.

Theoretical and Natural Science, Vol. 6, 140-146
Published 03 August 2023. © 2023 The Author(s). Published by EWA Publishing
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation Jiuhong Wang. The role and mechanism of adipose stem cells in facial anti-aging. TNS (2023) Vol. 6: 140-146. DOI: 10.54254/2753-8818/6/20230199.


ADSCs are stem cells found in adipose tissue that can self-renew in vitro and undergo multidirectional differentiation in containers. They may have anti-aging effects through their growth factors as well as their multidirectional differentiation function. In this paper, we searched PubMed, Web Of Science, CNKI, and other databases for related articles in recent years through relevant keywords, and the results showed that ADSCs have significant effects on facial anti-aging such as inhibiting skin wrinkle increase, whitening facial skin, and promoting hair regeneration. This paper presents a multifaceted analysis of the underlying mechanisms of action and related research on the application of adipose stem cells in facial skin anti-aging. It will enable medical aesthetic physicians to have a better understanding of the role and mechanism of ADSCs in facial anti-aging so that they can better provide healthy and standardized medical aesthetic services.


adipose stem cells, anti-aging, facial skin, natural aging, photoaging


1. Ganceviciene R, Liakou AI, Theodoridis A, et al. Skin anti-aging strategies. Dermatoendocrinol. 2012;4(3):308-319.

2. Robert L, Labat-Robert J, Robert AM: Physiology of skin aging. Clin Plast Surg 2012, 39(1):1- 8.

3. Helfrich YR, Sachs DL, Voorhees JJ: Overview of skin aging and photoaging. Dermatol Nurs 2008, 20(3):177-183; quiz 184.

4. Zuk PA, Zhu M, Mizuno H, et al. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001;7(2):211-228.

5. Kim JH, Jung M, Kim HS, et al. Adipose-derived stem cells as a new therapeutic modality for aging skin. Exp Dermatol. 2011;20(5):383-387.

6. McIntosh K, Zvonic S, Garrett S, et al. The immunogenicity of human adipose-derived cells: temporal changes in vitro. Stem Cells. 2006;24(5):1246-1253.

7. Wang JV, Schoenberg E, Zaya R, et al. The rise of stem cells in skin rejuvenation: A new frontier. Clin Dermatol. 2020;38(4):494-496.

8. Fisher GJ, Datta SC, Talwar HS, et al. Molecular basis of sun-induced premature skin aging and retinoid antagonism. Nature. 1996;379(6563):335-339.

9. Song SY, Jung JE, Jeon YR, et al. Determination of adipose-derived stem cell application on photo-aged fibroblasts, based on paracrine function. Cytotherapy. 2011;13(3):378-384.

10. Stevenson S, Taylor AH, Meskiri A, et al. Differing responses of human follicular and nonfollicular scalp cells in an in vitro wound healing assay: effects of estrogen on vascular endothelial growth factor secretion. Wound Repair Regen 2008, 16(2):243-253.

11. Kim HH, Lee MJ, Lee SR, et al. Augmentation of UV-induced skin wrinkling by infrared irradiation in hairless mice. Mech Ageing Dev. 2005;126(11):1170-1177.

12. Watson RE, Griffiths CE: Pathogenic aspects of cutaneous photoaging. J Cosmet Dermatol 2005, 4(4):230-236.

13. Kim WS, Park BS, Kim HK, et al. Evidence supporting antioxidant action of adipose-derived stem cells: protection of human dermal fibroblasts from oxidative stress. J Dermatol Sci. 2008;49(2):133-142.

14. Kim WS, Park BS, Park SH, et al. Antiwrinkle effect of adipose-derived stem cell: activation of dermal fibroblast by secretory factors. J Dermatol Sci. 2009;53(2):96-102.

15. Kim K, Fan Y, Lin G, et al. Synergistic Effect of Adipose-Derived Stem Cells and Fat Graft on Wrinkles in Aged Mice. Plast Reconstr Surg. 2019;143(6):1637-1646.

16. Szadvari I, Krizanova O, Babula P: Athymic nude mice as an experimental model for cancer treatment. Physiol Res 2016, 65(Suppl 4): S441-S453.

17. Pillaiyar T, Manickam M, Namasivayam V: Skin whitening agents: medicinal chemistry perspective of tyrosinase inhibitors. J Enzyme Inhib Med Chem 2017, 32(1):403-425.

18. Choi H, Ahn S, Lee BG, et al. Inhibition of skin pigmentation by an extract of Lepidium apetalum and its possible implication in IL-6 mediated signaling. Pigment Cell Res. 2005;18(6):439-446.

19. Kim WS, Park SH, Ahn SJ, et al. Whitening effect of adipose-derived stem cells: a critical role of TGF-beta 1. Biol Pharm Bull. 2008;31(4):606-610.

20. Jeon BJ, Kim DW, Kim MS, et al. Protective effects of adipose-derived stem cells against UVB-induced skin pigmentation. J Plast Surg Hand Surg. 2016;50(6):336-342.

21. Chang H, Park JH, Min KH, et al. Whitening effects of adipose-derived stem cells: a preliminary in vivo study. Aesthetic Plast Surg. 2014;38(1):230-233.

22. Zhang, C., Wang, D., Wang, J. et al. Escape of hair follicle stem cells causes stem cell exhaustion during aging. Nat Aging 1, 889–903 (2021).

23. Tomita Y, Akiyama M, Shimizu H: PDGF isoforms induce and maintain anagen phase of murine hair follicles. J Dermatol Sci 2006, 43(2):105-115.

24. Yano K, Brown LF, Detmar M: Control of hair growth and follicle size by VEGF-mediated angiogenesis. J Clin Invest 2001, 107(4):409-417.

25. Gentile P, Garcovich S: Advances in Regenerative Stem Cell Therapy in Androgenic Alopecia and Hair Loss: Wnt pathway, Growth-Factor, and Mesenchymal Stem Cell Signaling Impact Analysis on Cell Growth and Hair Follicle Development. Cells 2019, 8(5).

26. Watabe R, Yamaguchi T, Kabashima-Kubo R, et al. Leptin controls hair follicle cycling. Exp Dermatol. 2014;23(4):228-229.

27. Won CH, Yoo HG, Kwon OS, et al. Hair growth-promoting effects of adipose tissue-derived stem cells. J Dermatol Sci. 2010;57(2):134-137.

28. Tak YJ, Lee SY, Cho AR, et al. A randomized, double-blind, vehicle-controlled clinical study of hair regeneration using adipose-derived stem cell constituent extract in androgenetic alopecia. Stem Cells Transl Med. 2020;9(8):839-849.

29. Wu J, Yang Q, Wu S, et al. Adipose-Derived Stem Cell Exosomes Promoted Hair Regeneration. Tissue Eng Regen Med. 2021;18(4):685-691

Data Availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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Volume Title
Proceedings of the International Conference on Modern Medicine and Global Health (ICMMGH 2023)
ISBN (Print)
ISBN (Online)
Published Date
03 August 2023
Theoretical and Natural Science
ISSN (Print)
ISSN (Online)
© 2023 The Author(s)
Open Access
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Copyright © 2023 EWA Publishing. Unless Otherwise Stated