Theoretical and Natural Science

- The Open Access Proceedings Series for Conferences


Proceedings of the International Conference on Modern Medicine and Global Health (ICMMGH 2023)

Series Vol. 6 , 03 August 2023


Open Access | Article

Existing methods to improve immunotherapy's limitations: CAR-T cell therapy and checkpoint inhibitors

Sirui Nan * 1
1 Shenzhen college of international

* Author to whom correspondence should be addressed.

Theoretical and Natural Science, Vol. 6, 259-267
Published 03 August 2023. © 2023 The Author(s). Published by EWA Publishing
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation Sirui Nan. Existing methods to improve immunotherapy's limitations: CAR-T cell therapy and checkpoint inhibitors. TNS (2023) Vol. 6: 259-267. DOI: 10.54254/2753-8818/6/20230249.

Abstract

Immunotherapy is a form of treatment for cancer that works by provoking the immune system of the body into tracking down and destroying cancer cells. CAR-T-CT is a treatment that makes use of CAR-T cells (CARs), which are T cells (T-Cs) that have been modified in some way by the incorporation of engineered synthetic receptors. This therapy is designed to destroy cells that express a specific target antigen, and its primary objective is to do so by locating and killing those cells. Due to the fact that Immune CPI inhibits the production of specific proteins (checkpoint protein) on immune cells as well as on cancer cells thereby preventing the immune system from combating cancer, Immune CPI are used to treat cancer. By inhibiting the activity of these proteins, CPI is able to contribute to the process of stimulating the immune system to specifically target and destroy cancer cells. However, there are still some limitations that exist, and these have the potential to reduce the effectiveness of the treatment or produce some side effects that are life-threatening. This article makes a few suggestions for innovative steps that could be taken in order to both improve the current state of affairs and find answers to any problems that may arise in the near or distant future. The article makes these suggestions in order to improve the current state of affairs and find answers to any problems that may arise in the future.

Keywords

immunotherapy, CAR-T cell therapy, checkpoint inhibitors

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Data Availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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Volume Title
Proceedings of the International Conference on Modern Medicine and Global Health (ICMMGH 2023)
ISBN (Print)
978-1-915371-65-2
ISBN (Online)
978-1-915371-66-9
Published Date
03 August 2023
Series
Theoretical and Natural Science
ISSN (Print)
2753-8818
ISSN (Online)
2753-8826
DOI
10.54254/2753-8818/6/20230249
Copyright
© 2023 The Author(s)
Open Access
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Copyright © 2023 EWA Publishing. Unless Otherwise Stated