Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Series Vol. 6 , 03 August 2023
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Sepsis is a severe syndrome that is associated with both inflammatory responses and immune system dysfunctions. The most frequent location of injuries caused by sepsis is the respiratory system, followed by the digestive system, and the circulatory system. Researchers have revealed the relationship between T cells and sepsis. To be specific, during the pathology of sepsis, T cells could be damaged, deactivated, and inhibited, while they could also act as an agent that amplifies the sepsis syndrome. This paper focuses on analyzing 3 types of T cells: CD4+ T cells, CD8+ T cells, and regulatory T cells. The populations of the first two types would be reduced, while the functions of regulatory T cells could lead to further immunosuppression during sepsis. Although to date there is no effective treatment to cure this disease, treatment plans targeting immune stimulation and Treg suppression are also examined and analyzed in depth in this paper.
sepsis syndrome, cytokine, immunotherapy, T-cells.
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The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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