Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 21, 20 December 2023
Open
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The role of the 14-3-3 protein family in disease
* Author to whom correspondence should be addressed.
Abstract
14-3-3 protein is a dimer protein extracted from bovine brain cells, a highly conserved protein prevalent in eukaryotes. There are seven subtypes in mammals, respectively σ, ζ, β, γ, η, ε and τ. The subtypes differ in content and function. It was found that the protein interacts with corresponding ligand protein in regulating life activities, such as: cell cycle regulation, cell development, the transmission of cell signal molecules plays an important role. At the same time, related regulators have been developed based on cell-cell interaction. In recent years, the exploration of 14-3-3 protein has been deepening gradually. Inhibition or stabilizers of the 14-3-3 protein in question have been studied or discovered, and have become a new target for treating diseases. This paper reviews the effects of 14-3-3 protein on neurological disease, cardiovascular and cerebrovascular diseases and cancer are reviewed. It is found that protein subtypes affect the occurrence of diseases.
Keywords
14-3-3 protein, disease, neurological disease, cardiovascular disease and cerebrovascular disease, tumors.
References
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Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the 3rd International Conference on Biological Engineering and Medical Science
- ISBN (Print)
- 978-1-83558-215-2
- ISBN (Online)
- 978-1-83558-216-9
- Published Date
- 20 December 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/21/20230807
- Copyright
- 20 December 2023
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited