Theoretical and Natural Science

- The Open Access Proceedings Series for Conferences


Theoretical and Natural Science

Vol. 23, 20 December 2023


Open Access | Article

Review of the effects of chronic stress on human insomnia

Leyi Kang * 1
1 University of California San Diego

* Author to whom correspondence should be addressed.

Theoretical and Natural Science, Vol. 23, 18-21
Published 20 December 2023. © 2023 The Author(s). Published by EWA Publishing
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation Leyi Kang. Review of the effects of chronic stress on human insomnia. TNS (2023) Vol. 23: 18-21. DOI: 10.54254/2753-8818/23/20231011.

Abstract

While there are decent amounts of studies exploring the effects of chronic stress on sleep in animal models (e.g., rats), studies recruiting human subjects on this specific topic are rare in neuroscience and psychology. Thus, this paper aims to review the literature focusing on and mentioning chronic stress effects on human sleep, primarily based on experimental trials and clinical cases. Specifically, this review assesses the relationship between chronic stress (rather than acute stress and traumatic events) and insomnia in adult humans, the neurological and behavioral influence of chronic stress, and potential treatments for insomnia related to stress. The review was conducted using the PsycInfo database. Results from the reviewed literature show that chronic stress is associated with a decrease in neurogenesis and can be predicted by amygdala reactivity. Human subjects are likely to replicate results from rat models that show a decrease in REM sleep time under chronic stress and altered slow wave activities during sleep, and such deprivation of REM sleep can further alter hormonal levels in brain areas relating to stress and learning. Promisingly, there is evidence supporting the efficacy of cognitive and behavioral therapy for insomnia (CBT-I), conducted by professional therapists.

Keywords

chronic stress, insomnia, REM sleep, CBT

References

1. Leger, D., & Bayon, V. (2010b). Societal costs of insomnia. Sleep Medicine Reviews, 14(6), 379–389. https://doi.org/10.1016/j.smrv.2010.01.003

2. Morin, C. M., & Benca, R. M. (2012). Chronic insomnia. The Lancet, 379(9821), 1129–1141. https://doi.org/10.1016/s0140-6736(11)60750-2

3. Bonnet, M. H., & Arand, D. L. (2010). Hyperarousal and insomnia: State of the science. Sleep Medicine Reviews, 14(1), 9–15. https://doi.org/10.1016/j.smrv.2009.05.002

4. Dopheide, J. A. (2020). Insomnia overview: epidemiology, pathophysiology, diagnosis and monitoring, and nonpharmacologic therapy. The American Journal of Managed Care, 26(Suppl 4), S76–S84. https://doi.org/10.37765/ajmc.2020.42769

5. Hafner, M., Stepanek, M., Taylor, J., Troxel, W. M., & Van Stolk, C. (2017). Why sleep matters: The economic costs of insufficient sleep. In RAND Corporation eBooks. https://doi.org/10.7249/rb9962

6. Baglioni, C., Spiegelhalder, K., Regen, W., Feige, B., Nissen, C., Lombardo, C., Violani, C., Hennig, J., & Riemann, D. (2014). Insomnia disorder is associated with increased amygdala reactivity to insomnia-related stimuli. Sleep: Journal of Sleep and Sleep Disorders Research, 37(12), 1907-1917. https://doi.org/10.5665/sleep.4240

7. Li, C., Ma, X., Dong, M., Yin, Y., Hua, K., Li, M., Li, C., Zhan, W., Li, C., & Jiang, G. (2016). Abnormal spontaneous regional brain activity in primary insomnia: A resting-state functional magnetic resonance imaging study. Neuropsychiatric Disease and Treatment, 12, 8. https://www.proquest.com/scholarly-journals/abnormal-spontaneous-regional-brain-activity/docview/1812935487/se-2

8. Neylan, T. C., Mueller, S. G., Wang, Z., Metzler, T. J., Lenoci, M., Truran, D., Marmar, C. R., Weiner, M. W., & Schuff, N. (2010). Insomnia severity is associated with a decreased volume of the CA3/dentate gyrus hippocampal subfield. Biological Psychiatry, 68(5), 494-496. https://doi.org/10.1016/j.biopsych.2010.04.035

9. Kant, G. J., Pastel, R. H., Bauman, R. A., Meininger, G. R., Maughan, K. R., Robinson, T. N., Wright, W. L., & Covington, P. S. (1995). Effects of chronic stress on sleep in rats. Physiology & Behavior, 57(2), 359-365. https://doi.org/10.1016/0031-9384(94)00241-V

10. Machado, R. B., Tufik, S., & Suchecki, D. (2008). Chronic stress during paradoxical sleep deprivation increases paradoxical sleep rebound: Association with prolactin plasma levels and brain serotonin content. Psychoneuroendocrinology, 33(9), 1211-1224. https://doi.org/10. 1016/j.psyneuen.2008.06.007

11. Olini, N., Rothfuchs, I., Azzinnari, D., Pryce, C. R., Kurth, S., & Huber, R. (2017). Chronic social stress leads to altered sleep homeostasis in mice. Behavioural Brain Research, 327, 167-173. https://doi.org/10.1016/j.bbr.2017.03.022

12. Feige, B., Al-Shajlawi, A., Nissen, C., Voderholzer, U., Hornyak, M., Spiegelhalder, K., Kloepfer, C., Perlis, M. L., & Riemann, D. (2008). Does REM sleep contribute to subjective wake time in primary insomnia? A comparison of polysomnographic and subjective sleep in 100 patients. Journal of Sleep Research, 17(2), 180–190. https://doi.org/10.1111/j.1365-2869.2008.00651.x

13. Tafti, M., Villemin, E., Besset, A., & Billard, M. (1993). Slow wave activity deficiency in sleep maintenance insomnia patients. Sleep Res, 22, 575.

14. Guzman-Marin, R., Suntsova, N., Methippara, M., Greiffenstein, R., Szymusiak, R., & McGinty, D. (2005b). Sleep deprivation suppresses neurogenesis in the adult hippocampus of rats. European Journal of Neuroscience, 22(8), 2111–2116. https://doi.org/10.1111/j.1460-9568.2005.04376.x

15. Conrad, C. D. (2010). A critical review of chronic stress effects on spatial learning and memory. Progress in Neuro-Psychopharmacology & Biological Psychiatry, 34(5), 742-755. https://doi.org/10.1016/j.pnpbp.2009.11.003

16. Prather, A. A., Bogdan, R., & Hariri, A. R. (2013). Impact of sleep quality on amygdala reactivity, negative affect, and perceived stress. Psychosomatic Medicine, 75(4), 350-358. https://doi.org/10.1097/PSY.0b013e31828ef15b

17. Perlis, M. L., Sharpe, M., Smith, M. T., Greenblatt, D., & Giles, D. (2001). Behavioral treatment of insomnia: Treatment outcome and the relevance of medical and psychiatric morbidity. Journal of Behavioral Medicine, 24(3), 281-296. https://doi.org/10.1023/A:1010770807823

18. Ashworth, D. K., Sletten, T. L., Junge, M., Simpson, K., Clarke, D., Cunnington, D., & Rajaratnam, S. M. W. (2015). A randomized controlled trial of cognitive behavioral therapy for insomnia: An effective treatment for comorbid insomnia and depression. Journal of Counseling Psychology, 62(2), 115-123. https://doi.org/10.1037/cou0000059

Data Availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. Authors who publish this series agree to the following terms:

1. Authors retain copyright and grant the series right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this series.

2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the series's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this series.

3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See Open Access Instruction).

Volume Title
Proceedings of the 3rd International Conference on Biological Engineering and Medical Science
ISBN (Print)
978-1-83558-219-0
ISBN (Online)
978-1-83558-220-6
Published Date
20 December 2023
Series
Theoretical and Natural Science
ISSN (Print)
2753-8818
ISSN (Online)
2753-8826
DOI
10.54254/2753-8818/23/20231011
Copyright
20 December 2023
Open Access
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Copyright © 2023 EWA Publishing. Unless Otherwise Stated