Theoretical and Natural Science

- The Open Access Proceedings Series for Conferences


Theoretical and Natural Science

Vol. 8, 13 November 2023


Open Access | Article

Diagnosis and treatment of unipolar and bipolar depression in the early stage

Yiting Shi * 1
1 University of California, Irvine

* Author to whom correspondence should be addressed.

Theoretical and Natural Science, Vol. 8, 63-69
Published 13 November 2023. © 2023 The Author(s). Published by EWA Publishing
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation Yiting Shi. Diagnosis and treatment of unipolar and bipolar depression in the early stage. TNS (2023) Vol. 8: 63-69. DOI: 10.54254/2753-8818/8/20240360.

Abstract

Bipolar Disorder and Unipolar Depressive Disorder are both mental disorders that contain depressive episodes, and the patterns of depression are similar between the two diseases. People are likely to meet their clinicians for the first time when they experience depression while there is no significant evidence of the existence of mania episodes—the other episode of bipolar disorder. Therefore, it is likely that the clinicians misdiagnose the disorder, thus prescribing the wrong medication or applying therapies harmful to patients. For example, some antidepressants will stimulate the mania episode of bipolar patients, increasing the frequency of switch between extreme depression and mania, thus developing the results of bipolar disorder in the patients. At the same time, some mood stabilizers are not that effective to cure major depression compared to medication specialized in treating depression. This article aims at providing several diagnostic methods that can differentiate bipolar and unipolar disorders, and introducing some plausible therapies that work for the two disorders at the same time without severe harm or exacerbation.

Keywords

Bipolar Disorder, bipolar depression, diagnosis, unipolar depression, anti-depressant treatment

References

1. DeAngelis, T. (2021, November 1). Depression and anxiety escalate during COVID. Monitor on Psychology.

2. Shi J, Geng J, Yan R, Liu X, Chen Y, Zhu R, Wang X, Shao J, Bi K, Xiao M, Yao Z and Lu Q (2018) Differentiation of Transformed Bipolar Disorder from Unipolar Depression by Resting-State Functional Connectivity Within Reward Circuit. Front. Psychol. 9:2586.

3. Scaini, G., & Quevedo, J. (2023). The conundrum of antidepressant use in bipolar disorder. Molecular psychiatry, 28(3), 972–973.

4. O’Donovan, C., & Alda, M. (2020). Depression Preceding Diagnosis of Bipolar Disorder. Frontiers in psychiatry, 11, 500.

5. Shi J, Geng J, Yan R, Liu X, Chen Y, Zhu R, Wang X, Shao J, Bi K, Xiao M, Yao Z and Lu Q (2018) Differentiation of Transformed Bipolar Disorder from Unipolar Depression by Resting-State Functional Connectivity Within Reward Circuit. Front. Psychol. 9:2586.

6. Chen, C. K., Wu, L. S., Huang, M. C., Kuo, C. J., & Cheng, A. T. (2022). Antidepressant Treatment and Manic Switch in Bipolar I Disorder: A Clinical and Molecular Genetic Study. Journal of personalized medicine, 12(4), 615.

7. Wardhani, D.K. Unipolar Depression to Bipolar Conversion. Journal of Psychiatry Psychology and Behavioral Research; 2022.3(1).p:20-24.

8. Shao, J., Dai, Z., Zhu, R., Wang, X., Lu, Q., Yao, Z., Sun, Y., Wang, H., Tian, S., Bi, K., & Tao, S. (2019, August 12). Early identification of bipolar from unipolar ... - wiley online library. Early identification of bipolar from unipolar depression before manic episode: Evidence from dynamic rfMRI.

9. Penghong Liu, Qi Li, Aixia Zhang, Zhifen Liu, Ning Sun, Chunxia Yang, Yanfang Wang & Kerang Zhang (2020) Similar and Different Regional Homogeneity Changes Between Bipolar Disorder and Unipolar Depression: A Resting-State fMRI Study, Neuropsychiatric Disease and Treatment, 1087-1093.

10. Waller, J., Miao, T., Ikedionwu, I., & Lin, K. K. (2021, January 2). Reviewing applications of structural and functional MRI for bipolar disorder - japanese journal of radiology. SpringerLink.

11. Yasin, S., Hussain, S. A., Aslan, S., Raza, I., Muzammel, M., & Othmani, A. (2021, February 23). EEG based major depressive disorder and bipolar disorder detection using Neural Networks:A Review. Computer Methods and Programs in Biomedicine.

12. Jan, Z., Ai-Ansari, N., Mousa, O., Abd-Alrazaq, A., Ahmed, A., Alam, T., & Househ, M. (2021). The Role of Machine Learning in Diagnosing Bipolar Disorder: Scoping Review. Journal of medical Internet research, 23(11), e29749.

13. Tomasik, J., Han, S. Y. S., Barton-Owen, et al. (2021). A machine learning algorithm to differentiate bipolar disorder from major depressive disorder using an online mental health questionnaire and blood biomarker data. Translational psychiatry, 11(1), 41.

14. Post R. M. (2018). The New News about Lithium: An Underutilized Treatment in the United States. Neuropsychopharmacology: official publication of the American College of Neuropsychopharmacology, 43(5), 1174–1179.

15. Amare, A. T., Schubert, K. O., Hou, L., et al. (2021). Association of polygenic score for major depression with response to lithium in patients with bipolar disorder. Molecular psychiatry, 26(6), 2457–2470.

16. Surjan, J., Grossi, J. D., Del Porto, J. A., et al. (2022). Efficacy and Safety of Subcutaneous Esketamine in the Treatment of Suicidality in Major Depressive Disorder and Bipolar Depression. Clinical drug investigation, 42(10), 865–873.

17. Bahji, A., Hawken, E. R., Sepehry, A. A., Cabrera, C. A., & Vazquez, G. (2018). ECT beyond unipolar major depression: Systematic Review and meta‐analysis of electroconvulsive therapy in bipolar depression. Acta Psychiatrica Scandinavica, 139(3), 214–226.

18. Gazzaniga, M. S., Heatherton, T. F., & Halpern, D. F. (2014). Psychological science. W.W. Norton & Co.

19. Sit, D. K., McGowan, J., Wiltrout, C., Diler, R. S., Dills, J. (Jesse), Luther, J., Yang, A., Ciolino, J. D., Seltman, H., Wisniewski, S. R., Terman, M., & Wisner, K. L. (2018). Adjunctive bright light therapy for bipolar depression: A randomized double-blind placebo-controlled trial. American Journal of Psychiatry, 175(2), 131–139.

Data Availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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Volume Title
Proceedings of the 2nd International Conference on Modern Medicine and Global Health
ISBN (Print)
978-1-83558-111-7
ISBN (Online)
978-1-83558-112-4
Published Date
13 November 2023
Series
Theoretical and Natural Science
ISSN (Print)
2753-8818
ISSN (Online)
2753-8826
DOI
10.54254/2753-8818/8/20240360
Copyright
13 November 2023
Open Access
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Copyright © 2023 EWA Publishing. Unless Otherwise Stated