Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Vol. 24, 20 December 2023
* Author to whom correspondence should be addressed.
This paper examines how stress impacts depression and anxiety through neural responses to mistakes and rewards. Currently, mental health problems, specifically anxiety and depression, are on the rise. This paper presents a study on how stress affects depression and anxiety. To begin with, this paper describes two neural responses: Error-Related Negative Wave (ERN) and Reward Positive (RewP). ERN could be a significant biomarker of anxiety symptoms. RewP, however, is linked to depression. Based on previous studies, this paper posits that depressed patients exhibit lower RewP amplitude indicative of reduced sensitivity to rewards. Moreover, this paper combines previous studies to demonstrate that stress could impact the amplitude of ERN and RewP. To be more precise, stress could amplify the magnitude of ERN, indicating that people's neural response to errors is heightened, thereby resulting in higher levels of anxiety. However, stress may reduce the magnitude of RewP, indicating a decrease in reward sensitivity and potentially increasing the susceptibility to depression. In summary, this article offers insights on how to articulate the connections among stress, anxiety, depression, and related factors. Furthermore, this article introduces a novel perspective on approaches to treating and preventing anxiety and depression.
Anxiety, Depression, Error-Related Negativity, Reward Positivity
1. World Health Organization. (2023). Mental disorders.
2. Cole, S. L., Mehra, L. M., Cibrian, E., Cummings, E. M., Nelson, B. D., Hajcak, G., & Meyer, A. (2023). Relational victimization prospectively predicts increases in error-related brain activity and social anxiety in children and adolescents across two years. Developmental Cognitive Neuroscience,61, 101252.
3. Freeman, C., Carpentier, L., & Weinberg, A. (2023). Effects of the COVID-19 pandemic on neural responses to reward: A Quasi-experiment. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
4. Burani, K., Brush, C. J., Spahr, C., Slavich, G. M., Meyer, A., & Hajcak, G. (2023). Corporal Punishment Is Uniquely Associated With a Greater Neural Response to Errors and Blunted Neural Response to Rewards in Adolescence. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging, 8(2), 210-218.
5. Melton, E. M., Li, H., Benson, J., Sohn, P., Huang, L. H., Song, B. L., ... & Chang, T. Y. (2019). Myeloid Acat1/Soat1 KO attenuates pro-inflammatory responses in macrophages and protects against atherosclerosis in a model of advanced lesions. Journal of Biological Chemistry, 294(43), 15836-15849.
6. Weinberg, A. (2023). Pathways to depression: Dynamic associations between neural responses to appetitive cues in the environment, stress, and the development of illness. Psychophysiology,60(1), e14193.
7. Weinberg, A., Olvet, D. M., & Hajcak, G. (2010). Increased error-related brain activity in generalized anxiety disorder. Biological psychology,85(3), 472-480.
8. Meyer, A., Developing Psychiatric Biomarkers: a Review Focusing on the Error-Related Negativity as a Biomarker for Anxiety. Current Treatment Options in Psychiatry, 2016: p. 1-9
9. Weinberg A, Klein DN, Hajcak G. Increased errorrelated brain activity distinguishes generalized anxiety disorder with and without comorbid major depressive disorder. J Abnorm Psychol. 2012.
10. Weinberg A, Meyer A, Hale‐Rude E, Perlman G, Kotov R, Klein DN, et al. Error‐related negativity DERN] and sustained threat: conceptual framework and empirical evaluation in an adolescent sample. Psychophysiology. 2016;53D3]:372–85.
11. Weinberg, A., Dieterich, R., & Riesel, A. (2015). Errorrelated brain activity in the age of RDoC: A review of the literature. International Journal of Psychopbysiology, 98(2), 276-299.
12. Moser, J. S., Moran, T. P., Schroder, H. S., Donnellan, M. B., & Yeung, N. (2013). On the relationship between anxiety and error monitoring: a meta-analysis and conceptual framework. Frontiers in human neuroscience,7, 466.
13. Mrazek, M. D., Chin, J. M., Schmader, T., Hartson, K. A., Smallwood, J., and Schooler, J. W. (2011). Threatened to distraction: mind-wandering as a consequence of stereotype threat.J. Exp. Soc. Psychol. 47, 1243–1248. doi: 10.1016/j.jesp.2011.05.011
14. Gehring, W. J., Liu, Y., Orr, J. M., and Carp, J. (2012). “The error-related negativity (ERN/Ne),” in Oxford Handbook of Event-Related Potential Components, eds S. J. Luck and E. Kappenman (New York, NY: Oxford University Press), 231–291.
15. Shang, J., Fu, Y., Ren, Z., Zhang, T., Du, M., Gong, Q., & Lui, S. (2014). The common traits of the ACC and PFC in anxiety disorders in the DSM-5: Meta-analysis of voxel-based morphometry studies. PLOS ONE, 9(3), e93432.
16. Banica, I., Sandre, A., Shields, G. S., Slavich, G. M., & Weinberg, A. (2020). The error-related negativity (ERN) moderates the association between interpersonal stress and anxiety symptoms six months later. International Journal of Psychophysiology, 153, 27-36.
17. Catalán-Aguilar, J., González-Bono, E., Lozano-García, A., Tormos-Pons, P., Hampel, K. G., Villanueva, V., & Cano-López, I. (2023). Stress phenotypes in epilepsy: impact on cognitive functioning and quality of life. Frontiers in Psychology.
18. Moser, J. S., Moran, T. P., Schroder, H. S., Donnellan, M. B., & Yeung, N. (2013). On the relationship between anxiety and error monitoring: a meta-analysis and conceptual framework. Frontiers in human neuroscience, 7, 466
19. Riesel, A., Kathmann, N., Wüllhorst, V., Banica, I., & Weinberg, A. (2019). Punishment has a persistent effect on error-related brain activity in highly anxious individuals twenty-four hours after conditioning. International Journal of Psychophysiology, 146, 63-72.
20. Proudfit, G. H. (2015). The reward positivity: From basic research on reward to a biomarker for depression. Psychophysiology, 52(4), 449-459.
21. Clayson, P. E., Carbine, K. A., & Larson, M. J. (2020). A registered report of error-related negativity and reward positivity as biomarkers of depression: P-Curving the evidence. International Journal of Psychophysiology, 150, 50-72.
22. Proudfit, G. H., Bress, J. N., Foti, D., Kujawa, A., & Klein, D. N. (2015). Depression and event-related potentials: Emotional disengagement and reward insensitivity. Current opinion in psychology, 4, 110-113.
23. Bress, J. N., Smith, E., Foti, D., Klein, D. N., & Hajcak, G. (2015). Neural response to reward and depressive symptoms in late childhood to early adolescence. Biological Psychology, 89(1), 156-162.
24. Bogdan, R., & Pizzagalli, D. A. (2006). Acute stress reduces reward responsiveness: implications for depression. Biological Psychiatry, 60(10), 1147-1154.
25. Arnsten, A. F. (2009). Stress signalling pathways that impair prefrontal cortex structure and function. Nature reviews neuroscience, 10(6), 410-422.
26. Baik, J. H. (2020). Stress and the dopaminergic reward system. Experimental & molecular medicine, 52(12), 1879-1890.
27. Russo, S. J., & Nestler, E. J. (2013). The brain reward circuitry in mood disorders. Nature Reviews Neuroscience, 14(9), 609-625.
28. Pizzagalli, D. A. (2014). Depression, stress, and anhedonia: Toward a synthesis and integrated model. Annual Review of Clinical Psychology, 10, 393-423.
29. Korgaonkar, M. S., Fornito, A., Williams, L. M., & Grieve, S. M. (2014). Abnormal structural networks characterize major depressive disorder: a connectome analysis. Biological Psychiatry, 76(7), 567-574.
30. Li, P., Peng, W., Li, H., & Holroyd, C. B. (2018). Electrophysiological measures reveal the role of anterior cingulate cortex in learning from unreliable feedback. Cognitive, Affective, & Behavioral Neuroscience, 18, 949-963.
31. M., Shirotsuki, K., & Sugaya, N. (2021). Cognitive–behavioral therapy for management of mental health and stress-related disorders: Recent advances in techniques and technologies. BioPsychoSocial medicine, 15(1), 1-4.
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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