Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 17, 04 December 2023
Open
Access | Article
Review of the association between non-coding RNAs and environmental exposure
* Author to whom correspondence should be addressed.
Abstract
Disease development is a consequence of the combination of genetic and environmental factors. Epigenetics can regulate gene expression without altering DNA sequence. There are different types of epigenetic regulation, including DNA methylation, histone modification and non-coding RNAs. Research has shown epigenetic regulation plays an essential role in environmental exposure and disease development. The role of DNA methylation and histone modification is well characterized so far. While the importance of non-coding RNA in disease development has gained more attention recently, the elucidation of the exposure-non coding RNA-disease pathway is still under much investigation. This review aims to provide a general review of ncRNA functions, focusing on research progress highlighting the association between a variety of exposure and non-coding RNAs and the hope of demonstrating how non-coding RNA can serve as biomarkers for preventive and therapeutic goals upon environmental exposure.
Keywords
Epigenetics, Non-Coding RNA, Environmental Exposure, Gene Regulation
References
1. Leff, T., et al., Diabetes and Exposure to Environmental Lead (Pb). Toxics, 2018. 6(3).
2. Tasin, F.R., et al., On-going consequences of in utero exposure of Pb: An epigenetic perspective. J Appl Toxicol, 2022.
3. Ruckart, P.Z., et al., The Flint Water Crisis: A Coordinated Public Health Emergency Response and Recovery Initiative. J Public Health Manag Pract, 2019. 25 Suppl 1, Lead Poisoning Prevention(Suppl 1 LEAD POISONING PREVENTION): p. S84-S90.
4. Sen, A., et al., Lead exposure induces changes in 5-hydroxymethylcytosine clusters in CpG islands in human embryonic stem cells and umbilical cord blood. Epigenetics, 2015. 10(7): p. 607-21.
5. Ellison, E.M., E.L. Abner, and M.A. Lovell, Multiregional analysis of global 5-methylcytosine and 5-hydroxymethylcytosine throughout the progression of Alzheimer's disease. J Neurochem, 2017. 140(3): p. 383-394.
6. Bihaqi, S.W., et al., Infant exposure to lead (Pb) and epigenetic modifications in the aging primate brain: implications for Alzheimer's disease. J Alzheimers Dis, 2011. 27(4): p. 819-33.
7. Hernandez-Meza, G., et al., DNA Methylation Profiling of Human Hepatocarcinogenesis. Hepatology, 2021. 74(1): p. 183-199.
8. Zeybel, M., et al., Differential DNA methylation of genes involved in fibrosis progression in non-alcoholic fatty liver disease and alcoholic liver disease. Clin Epigenetics, 2015. 7: p. 25.
9. Macfarlane, L.A. and P.R. Murphy, MicroRNA: Biogenesis, Function and Role in Cancer. Curr Genomics, 2010. 11(7): p. 537-61.
10. Lee, R.C., R.L. Feinbaum, and V. Ambros, The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, 1993. 75(5): p. 843-54.
11. Ardekani, A.M. and M.M. Naeini, The Role of MicroRNAs in Human Diseases. Avicenna J Med Biotechnol, 2010. 2(4): p. 161-79.
12. Ambros, V., et al., A uniform system for microRNA annotation. RNA, 2003. 9(3): p. 277-9.
13. Kim, V.N., MicroRNA biogenesis: coordinated cropping and dicing. Nat Rev Mol Cell Biol, 2005. 6(5): p. 376-85.
14. Bartel, D.P., MicroRNAs: genomics, biogenesis, mechanism, and function. Cell, 2004. 116(2): p. 281-97.
15. Saini, H.K., S. Griffiths-Jones, and A.J. Enright, Genomic analysis of human microRNA transcripts. Proc Natl Acad Sci U S A, 2007. 104(45): p. 17719-24.
16. Goodfellow, S.J. and R.J. White, Regulation of RNA polymerase III transcription during mammalian cell growth. Cell Cycle, 2007. 6(19): p. 2323-6.
17. Krützfeldt, J., et al., Silencing of microRNAs in vivo with 'antagomirs'. Nature, 2005. 438(7068): p. 685-9.
18. Zhao, Y., E. Samal, and D. Srivastava, Serum response factor regulates a muscle-specific microRNA that targets Hand2 during cardiogenesis. Nature, 2005. 436(7048): p. 214-20.
19. Naguibneva, I., et al., The microRNA miR-181 targets the homeobox protein Hox-A11 during mammalian myoblast differentiation. Nat Cell Biol, 2006. 8(3): p. 278-84.
20. Izzotti, A., et al., Downregulation of microRNA expression in the lungs of rats exposed to cigarette smoke. FASEB J, 2009. 23(3): p. 806-12.
21. Krauskopf, J., et al., The human circulating miRNome reflects multiple organ disease risks in association with short-term exposure to traffic-related air pollution. Environ Int, 2018. 113: p. 26-34.
22. Rodosthenous, R.S., et al., Ambient particulate matter and microRNAs in extracellular vesicles: a pilot study of older individuals. Part Fibre Toxicol, 2016. 13: p. 13.
23. Chen, C., et al., MicroRNA-191, regulated by HIF-2α, is involved in EMT and acquisition of a stem cell-like phenotype in arsenite-transformed human liver epithelial cells. Toxicol In Vitro, 2018. 48: p. 128-136.
24. Ren, X., et al., Arsenic responsive microRNAs in vivo and their potential involvement in arsenic-induced oxidative stress. Toxicol Appl Pharmacol, 2015. 283(3): p. 198-209.
25. Ngalame, N.N., M.P. Waalkes, and E.J. Tokar, Silencing KRAS Overexpression in Cadmium-Transformed Prostate Epithelial Cells Mitigates Malignant Phenotype. Chem Res Toxicol, 2016. 29(9): p. 1458-67.
26. Hassan, F., et al., MiR-101 and miR-144 regulate the expression of the CFTR chloride channel in the lung. PLoS One, 2012. 7(11): p. e50837.
27. Uchida, S. and S. Dimmeler, Long noncoding RNAs in cardiovascular diseases. Circ Res, 2015. 116(4): p. 737-50.
28. Xie, C., et al., NONCODEv4: exploring the world of long non-coding RNA genes. Nucleic Acids Res, 2014. 42(Database issue): p. D98-103.
29. Derrien, T., et al., The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression. Genome Res, 2012. 22(9): p. 1775-89.
30. Cabili, M.N., et al., Integrative annotation of human large intergenic noncoding RNAs reveals global properties and specific subclasses. Genes Dev, 2011. 25(18): p. 1915-27.
31. Heward, J.A. and M.A. Lindsay, Long non-coding RNAs in the regulation of the immune response. Trends Immunol, 2014. 35(9): p. 408-19.
32. May, J.M., et al., Long and short non-coding RNA and radiation response: a review. Transl Res, 2021. 233: p. 162-179.
33. Hu, X., et al., Knockdown of lncRNA HOTAIR sensitizes breast cancer cells to ionizing radiation through activating miR-218. Biosci Rep, 2019. 39(4).
34. Marín-Béjar, O., et al., Pint lincRNA connects the p53 pathway with epigenetic silencing by the Polycomb repressive complex 2. Genome Biol, 2013. 14(9): p. R104.
35. Ishii, N., et al., Identification of a novel non-coding RNA, MIAT, that confers risk of myocardial infarction. J Hum Genet, 2006. 51(12): p. 1087-1099.
36. Yan, B., et al., lncRNA-MIAT regulates microvascular dysfunction by functioning as a competing endogenous RNA. Circ Res, 2015. 116(7): p. 1143-56.
37. Faghihi, M.A., et al., Expression of a noncoding RNA is elevated in Alzheimer's disease and drives rapid feed-forward regulation of beta-secretase. Nat Med, 2008. 14(7): p. 723-30.
38. Kerin, T., et al., A noncoding RNA antisense to moesin at 5p14.1 in autism. Sci Transl Med, 2012. 4(128): p. 128ra40.
39. Martínez-Guitarte, J.L., R. Planelló, and G. Morcillo, Overexpression of long non-coding RNAs following exposure to xenobiotics in the aquatic midge Chironomus riparius. Aquat Toxicol, 2012. 110-111: p. 84-90.
40. Bhan, A., et al., Bisphenol-A and diethylstilbestrol exposure induces the expression of breast cancer associated long noncoding RNA HOTAIR in vitro and in vivo. J Steroid Biochem Mol Biol, 2014. 141: p. 160-70.
41. Bi, H., et al., Microarray analysis of long non-coding RNAs in COPD lung tissue. Inflamm Res, 2015. 64(2): p. 119-26.
42. Huang, X. and G. Wong, An old weapon with a new function: PIWI-interacting RNAs in neurodegenerative diseases. Transl Neurodegener, 2021. 10(1): p. 9.
43. Kim, K.W., PIWI Proteins and piRNAs in the Nervous System. Mol Cells, 2019. 42(12): p. 828-835.
44. Hutvagner, G. and M.J. Simard, Argonaute proteins: key players in RNA silencing. Nat Rev Mol Cell Biol, 2008. 9(1): p. 22-32.
45. Houwing, S., et al., A role for Piwi and piRNAs in germ cell maintenance and transposon silencing in Zebrafish. Cell, 2007. 129(1): p. 69-82.
46. Vagin, V.V., et al., A distinct small RNA pathway silences selfish genetic elements in the germline. Science, 2006. 313(5785): p. 320-4.
47. Czech, B., et al., piRNA-Guided Genome Defense: From Biogenesis to Silencing. Annu Rev Genet, 2018. 52: p. 131-157.
48. Perera, B.P.U., et al., Somatic expression of piRNA and associated machinery in the mouse identifies short, tissue-specific piRNA. Epigenetics, 2019. 14(5): p. 504-521.
49. Czech, B. and G.J. Hannon, One Loop to Rule Them All: The Ping-Pong Cycle and piRNA-Guided Silencing. Trends Biochem Sci, 2016. 41(4): p. 324-337.
50. Shen, L., et al., [PIWI/piRNA complex-mediated regulation of spermatogenesis]. Zhonghua Nan Ke Xue, 2021. 27(3): p. 262-268.
51. Toth, G.P., et al., Development of omics biomarkers for estrogen exposure using mRNA, miRNA and piRNAs. Aquat Toxicol, 2021. 235: p. 105807.
52. Han, R., et al., piRNA-DQ722010 contributes to prostate hyperplasia of the male offspring mice after the maternal exposed to microcystin-leucine arginine. Prostate, 2019. 79(7): p. 798-812.
53. Li, Y., et al., Effects of fluoride on PIWI-interacting RNA expression profiling in testis of mice. Chemosphere, 2021. 269: p. 128727.
Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. Authors who publish this series agree to the following terms:
1. Authors retain copyright and grant the series right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this series.
2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the series's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this series.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See Open Access Instruction).
- Volume Title
- Proceedings of the 2nd International Conference on Modern Medicine and Global Health
- ISBN (Print)
- 978-1-83558-197-1
- ISBN (Online)
- 978-1-83558-198-8
- Published Date
- 04 December 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/17/20240619
- Copyright
- © 2023 The Author(s)
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited