Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 20, 20 December 2023
Open
Access | Article
The role of glial cells in schizophrenic brain
* Author to whom correspondence should be addressed.
Abstract
Schizophrenia, as a complex neurological disorder, has many distressing symptoms such as hallucinations and some of the common mood or cognitive disorders commonly associated with mental illness. Once suffering from schizophrenia, people’s work and life will be greatly troubled. It is also often associated with other psychiatric disorders, which makes it extremely difficult to treat clinically. However, a diverse of different studies have been able to identify a clear link with neurotransmitter signaling pathways and some brain activity, such as dopamine projection pathways and a significant reduction in gray matter in patients. This research will focus on another dimension, namely the reduction of gray matter volume, to investigate the relationship between oligodendrocyte and astrocyte function and schizophrenia, in an attempt to provide a new vision for the clinical treatment system. In addition, it is expected that this research can also provide a new idea for the development of new drugs for schizophrenia.
Keywords
glial cells, astrocytes, oligodendrocytes, schizophrenia
References
1. Norton, W. T. and Poduslo, S. E., "Myelination in rat brain: changes in myelin composition during brain maturation," J Neurochem 21, 759–73 (1973).
2. Gouvêa-Junqueira, D., Falvella, A. C. B., Antunes, A. S. L. M., Seabra, G., Brandão-Teles, C., Martins-de-Souza, D. and Crunfli, F., "Novel Treatment Strategies Targeting Myelin and Oligodendrocyte Dysfunction in Schizophrenia," Frontiers in psychiatry, 11, 379.
3. Moore, S., Meschkat, M., Ruhwedel, T., Trevisiol, A., Tzvetanova, I. D., Battefeld, A., Kusch, K., Kole, M. H. P., Strenzke, N., Möbius, W., de Hoz, L. and Nave, K. A. (2020). "A role of oligodendrocytes in information processing," Nat Commun 11, 5497 (2020).
4. Coyle J. T., "The glutamatergic dysfunction hypothesis for schizophrenia," Harvard Review of Psychiatry 3, 241-253 (1996).
5. Notter T., "Astrocytes in schizophrenia," Brain and Neuroscience Advances 5, 239821282110091 (2021).
6. Gong, Q., Lui, S. and Sweeney, J. A., "A Selective Review of Cerebral Abnormalities in Patients With First-Episode Schizophrenia Before and After Treatment," The American journal of psychiatry 173, 232–243 (2016).
7. de Oliveira Figueiredo, E. C., Calì, C., Petrelli, F. and Bezzi, P. "Emerging evidence for astrocyte dysfunction in schizophrenia," Glia 70, 1585–1604 (2022).
8. Costa, K. M. and Schoenbaum, G., "Dopamine," Current biology: CB 32, R817–R824 (2022).
9. Shen, Z., Xiang, M., Chen, C., Ding, F., Wang, Y., Shang, C., Xin, L., Zhang, Y. and Cui, X., "Glutamate excitotoxicity: Potential therapeutic target for ischemic stroke," Biomedicine & pharmacotherapy 151, 113125 (2022).
10. Crawford, P. and Go, K. V., "Schizophrenia," American family physician 106, 388–396 (2022).
Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. Authors who publish this series agree to the following terms:
1. Authors retain copyright and grant the series right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this series.
2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the series's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this series.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See Open Access Instruction).
- Volume Title
- Proceedings of the 3rd International Conference on Biological Engineering and Medical Science
- ISBN (Print)
- 978-1-83558-213-8
- ISBN (Online)
- 978-1-83558-214-5
- Published Date
- 20 December 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/20/20230704
- Copyright
- 20 December 2023
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited