Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Vol. 27, 20 December 2023
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DNA is the most important code for deciphering human genetic information. It finally determines proteins through the central dogma. Therefore, gene mutations can cause various diseases. Cancer is one of the most difficult-to-cure diseases caused by mutations. Acute myeloid leukemia is one of the subtypes of bone marrow cancer, this essay will predominantly focus on the study of the mutation gene NPM1 (nucleophosmin 1). In order to understand the differences between the mutated gene NPM1 and other mutated genes, a cohort study analysis of NPM1 is needed. This research helps better understanding of cancer and the variation of NPM1 compared to the others. By researching and analyzing direct clinical data, this essay will contribute to the understanding of cancer and help turn a scientific blank message into a more simple and understandable manner. However, the limitation of this study is insufficient or even missing data. With the development of research and the improvement of data, future studies will be more accurate and effective, providing a more effective reference for exploring targeted therapy of acute myeloid leukemia.
Bone marrow cancer, acute myeloid leukemia, mutation gene NPM1
1. 10 Oct. 2023 one Marrow Cancer: Symptoms, Treatment, and Outlook Medical News Today Med Lexicon International
2. Thol F Ganser A 2020 Treatment of Relapsed Acute Myeloid Leukemia Curr Treat Options Oncol Jun 29 21 8 66
3. 11 Oct. 2023 Bone Marrow Cancers: What You Need to Know WebMD
4. Ravandi F Stone R Acute Promyelocytic Leukemia: A Perspective. Clin Lymphoma Myeloma Leuk 2017 Sep 17 9 543-544
5. 10 Oct 2023 Key Statistics for Acute Myeloid Leukemia (AML) American Cancer Society
6. 2023 PDQ Adult Treatment Editorial Board. Acute Myeloid Leukemia Treatment (PDQ®): Patient Version
7. 11 Oct 2023 Treatment Response Rates for Acute Myeloid Leukemia (AML) American Cancer Society
8. B J Bain 2017 WHO Classification of Leukemia Reference Module in Life Sciences Elsevier
9. Tabbò F et al 2021 The ALK receptor tyrosine kinase journey: From physiological roles to pathological disruptions In Therap Strat to Overcome ALK Resistance in Cancer pp 1-29
10. 10 Oct 2023 GDC portal.gdc.cancer.gov/analysis?analysisId=2023-09-09T12%3A06%3A 54.333Z&analysisTableTab=result
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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