Theoretical and Natural Science

- The Open Access Proceedings Series for Conferences


Theoretical and Natural Science

Vol. 27, 20 December 2023


Open Access | Article

Cohort analysis for the present mutation of NPM1 in bone marrow cancer

Jing Wang * 1
1 American School Hong Kong

* Author to whom correspondence should be addressed.

Theoretical and Natural Science, Vol. 27, 101-106
Published 20 December 2023. © 2023 The Author(s). Published by EWA Publishing
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation Jing Wang. Cohort analysis for the present mutation of NPM1 in bone marrow cancer. TNS (2023) Vol. 27: 101-106. DOI: 10.54254/2753-8818/27/20240709.

Abstract

DNA is the most important code for deciphering human genetic information. It finally determines proteins through the central dogma. Therefore, gene mutations can cause various diseases. Cancer is one of the most difficult-to-cure diseases caused by mutations. Acute myeloid leukemia is one of the subtypes of bone marrow cancer, this essay will predominantly focus on the study of the mutation gene NPM1 (nucleophosmin 1). In order to understand the differences between the mutated gene NPM1 and other mutated genes, a cohort study analysis of NPM1 is needed. This research helps better understanding of cancer and the variation of NPM1 compared to the others. By researching and analyzing direct clinical data, this essay will contribute to the understanding of cancer and help turn a scientific blank message into a more simple and understandable manner. However, the limitation of this study is insufficient or even missing data. With the development of research and the improvement of data, future studies will be more accurate and effective, providing a more effective reference for exploring targeted therapy of acute myeloid leukemia.

Keywords

Bone marrow cancer, acute myeloid leukemia, mutation gene NPM1

References

1. 10 Oct. 2023 one Marrow Cancer: Symptoms, Treatment, and Outlook Medical News Today Med Lexicon International

2. Thol F Ganser A 2020 Treatment of Relapsed Acute Myeloid Leukemia Curr Treat Options Oncol Jun 29 21 8 66

3. 11 Oct. 2023 Bone Marrow Cancers: What You Need to Know WebMD

4. Ravandi F Stone R Acute Promyelocytic Leukemia: A Perspective. Clin Lymphoma Myeloma Leuk 2017 Sep 17 9 543-544

5. 10 Oct 2023 Key Statistics for Acute Myeloid Leukemia (AML) American Cancer Society

6. 2023 PDQ Adult Treatment Editorial Board. Acute Myeloid Leukemia Treatment (PDQ®): Patient Version

7. 11 Oct 2023 Treatment Response Rates for Acute Myeloid Leukemia (AML) American Cancer Society

8. B J Bain 2017 WHO Classification of Leukemia Reference Module in Life Sciences Elsevier

9. Tabbò F et al 2021 The ALK receptor tyrosine kinase journey: From physiological roles to pathological disruptions In Therap Strat to Overcome ALK Resistance in Cancer pp 1-29

10. 10 Oct 2023 GDC portal.gdc.cancer.gov/analysis?analysisId=2023-09-09T12%3A06%3A 54.333Z&analysisTableTab=result

Data Availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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Volume Title
Proceedings of the 2nd International Conference on Modern Medicine and Global Health
ISBN (Print)
978-1-83558-237-4
ISBN (Online)
978-1-83558-238-1
Published Date
20 December 2023
Series
Theoretical and Natural Science
ISSN (Print)
2753-8818
ISSN (Online)
2753-8826
DOI
10.54254/2753-8818/27/20240709
Copyright
20 December 2023
Open Access
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Copyright © 2023 EWA Publishing. Unless Otherwise Stated