Theoretical and Natural Science

- The Open Access Proceedings Series for Conferences


Theoretical and Natural Science

Vol. 33, 08 March 2024


Open Access | Article

Ethnic and Geographic Disparities in Helicobacter pylori Infection: Unraveling the Complexities of Gastric Cancer Prevalence

Anni Chen * 1
1 New York University

* Author to whom correspondence should be addressed.

Theoretical and Natural Science, Vol. 33, 130-135
Published 08 March 2024. © 2023 The Author(s). Published by EWA Publishing
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation Anni Chen. Ethnic and Geographic Disparities in Helicobacter pylori Infection: Unraveling the Complexities of Gastric Cancer Prevalence. TNS (2024) Vol. 33: 130-135. DOI: 10.54254/2753-8818/33/20240891.

Abstract

This literature review delves into the complex relationship between Helicobacter pylori infection and gastric cancer, focusing on ethnic and geographic disparities. It examines the varying prevalence of H. pylori across different regions and ethnic groups, the pathogenicity of different bacterial strains, and the influence of genetic, dietary, and socio-economic factors on gastric cancer incidence. The review identifies critical research gaps and underscores the need for an integrated approach to understand these disparities better and develop targeted prevention and treatment strategies.

Keywords

Helicobacter pylori, Gastric Cancer, Ethnic Disparities, Geographic Variability, Socio-economic Factors

References

1. Bray F, Laversanne M, Weiderpass E, Soerjomataram I. The ever-increasing importance of cancer as a leading cause of premature death worldwide. Cancer. 2021;127(16):3029-3030. doi:10.1002/cncr.33587

2. Sung H, Ferlay J, Siegel RL, et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries. CA Cancer J Clin. 2021;71(3):209-249. doi:10.3322/caac.21660

3. Schistosomes, liver flukes and Helicobacter pylori. IARC Monogr Eval Carcinog Risks Hum. 1994;61:1-241.

4. Martinsen TC, Bergh K, Waldum HL. Gastric juice: a barrier against infectious diseases. Basic Clin Pharmacol Toxicol. 2005;96(2):94-102. doi:10.1111/j.1742-7843.2005.pto960202.x

5. Berger A. Scientists discover how helicobacter survives gastric acid. BMJ. 2000;320(7230):268.

6. Piscione M, Mazzone M, Di Marcantonio MC, Muraro R, Mincione G. Eradication of Helicobacter pylori and Gastric Cancer: A Controversial Relationship. Front Microbiol. 2021;12:630852. Published 2021 Feb 4. doi:10.3389/fmicb.2021.630852

7. You HM, Hu TM. Advances in understanding the relationship between the Helicobacter pylori CagA gene and diseases of the digestive system. Shijie Huaren Xiaohua Zazhi 2013; 21(16): 1505-1510

8. de Martel C, Parsonnet J. Helicobacter pylori infection and gender: a meta-analysis of population-based prevalence surveys. Dig Dis Sci. 2006;51(12):2292-2301. doi:10.1007/s10620-006-9210-5

9. Goodman KJ, Cockburn M. The role of epidemiology in understanding the health effects of Helicobacter pylori. Epidemiology. 2001;12(2):266-271. doi:10.1097/00001648-200103000-00023

10. Bardhan PK. Epidemiological features of Helicobacter pylori infection in developing countries. Clin Infect Dis. 1997;25(5):973-978. doi:10.1086/516067

11. Shirani M, Pakzad R, Haddadi MH, et al. The global prevalence of gastric cancer in Helicobacter pylori-infected individuals: a systematic review and meta-analysis. BMC Infect Dis. 2023;23(1):543. Published 2023 Aug 19. doi:10.1186/s12879-023-08504-5

12. Mbulaiteye SM, Hisada M, El-Omar EM. Helicobacter Pylori associated global gastric cancer burden. Front Biosci (Landmark Ed). 2009;14(4):1490-1504. Published 2009 Jan 1. doi:10.2741/3320

13. Fock KM, Ang TL. Epidemiology of Helicobacter pylori infection and gastric cancer in Asia. J Gastroenterol Hepatol. 2010;25(3):479-486. doi:10.1111/j.1440-1746.2009.06188.x

14. Windsor HM, Abioye-Kuteyi EA, Leber JM, Morrow SD, Bulsara MK, Marshall BJ. Prevalence of Helicobacter pylori in Indigenous Western Australians: comparison between urban and remote rural populations. Med J Aust. 2005;182(5):210-213.

15. Wong BC, Lam SK, Ching CK, et al. Differential Helicobacter pylori infection rates in two contrasting gastric cancer risk regions of South China. China Gastric Cancer Study Group. J Gastroenterol Hepatol. 1999;14(2):120-125. doi:10.1046/j.1440-1746.1999.01823.x

16. Ang TL, Fock KM, Dhamodaran S, Teo EK, Tan J. Racial differences in Helicobacter pylori, serum pepsinogen and gastric cancer incidence in an urban Asian population. J Gastroenterol Hepatol. 2005;20(10):1603-1609. doi:10.1111/j.1440-1746.2005.03898.x

17. Hoang TT, Bengtsson C, Phung DC, Sörberg M, Granström M. Seroprevalence of Helicobacter pylori infection in urban and rural Vietnam. Clin Diagn Lab Immunol. 2005;12(1):81-85. doi:10.1128/CDLI.12.1.81-85.2005

18. Zaidi SF. Helicobacter pylori associated Asian enigma: Does diet deserve distinction?. World J Gastrointest Oncol. 2016;8(4):341-350. doi:10.4251/wjgo.v8.i4.341

19. Blaser MJ, Perez-Perez GI, Kleanthous H, et al. Infection with Helicobacter pylori strains possessing cagA is associated with an increased risk of developing adenocarcinoma of the stomach. Cancer Res. 1995;55(10):2111-2115.

20. Cover TL. The vacuolating cytotoxin of Helicobacter pylori. Mol Microbiol. 1996;20(2):241-246. doi:10.1111/j.1365-2958.1996.tb02612.x

21. Gerhard M, Lehn N, Neumayer N, et al. Clinical relevance of the Helicobacter pylori gene for blood-group antigen-binding adhesin. Proc Natl Acad Sci U S A. 1999;96(22):12778-12783. doi:10.1073/pnas.96.22.12778

22. Singh K, Ghoshal UC. Causal role of Helicobacter pylori infection in gastric cancer: an Asian enigma. World J Gastroenterol. 2006;12(9):1346-1351. doi:10.3748/wjg.v12.i9.1346

23. Kinoshita Y, Kawanami C, Kishi K, Nakata H, Seino Y, Chiba T. Helicobacter pylori independent chronological change in gastric acid secretion in the Japanese. Gut. 1997;41(4):452-458. doi:10.1136/gut.41.4.452

24. Kuipers EJ, Lee A, Klinkenberg-Knol EC, Meuwissen SG. Review article: the development of atrophic gastritis--Helicobacter pylori and the effects of acid suppressive therapy. Aliment Pharmacol Ther. 1995;9(4):331-340. doi:10.1111/j.1365-2036.1995.tb00391.x

25. Kuipers EJ, Lundell L, Klinkenberg-Knol EC, et al. Atrophic gastritis and Helicobacter pylori infection in patients with reflux esophagitis treated with omeprazole or fundoplication. N Engl J Med. 1996;334(16):1018-1022. doi:10.1056/NEJM199604183341603

26. Bizri AR, Nuwayhid IA, Hamadeh GN, Steitieh SW, Choukair AM, Musharrafieh UM. Association between hepatitis A virus and Helicobacter pylori in a developing country: the saga continues. J Gastroenterol Hepatol. 2006;21(10):1615-1621. doi:10.1111/j.1440-1746.2006.04268.x

27. Zhang YY, Xia HH, Zhuang ZH, Zhong J. Review article: 'true' re-infection of Helicobacter pylori after successful eradication--worldwide annual rates, risk factors and clinical implications. Aliment Pharmacol Ther. 2009;29(2):145-160. doi:10.1111/j.1365-2036.2008.03873.x

28. Seel DJ, Kawabata T, Nakamura M, et al. N-nitroso compounds in two nitrosated food products in southwest Korea. Food Chem Toxicol. 1994;32(12):1117-1123. doi:10.1016/0278-6915(94)90127-9

29. Tsugane S, Sasazuki S. Diet and the risk of gastric cancer: review of epidemiological evidence. Gastric Cancer. 2007;10(2):75-83. doi:10.1007/s10120-007-0420-0

30. Cohen MM. Role of endogenous prostaglandins in gastric secretion and mucosal defense. Clin Invest Med. 1987;10(3):226-231.

31. Fox JG, Dangler CA, Taylor NS, King A, Koh TJ, Wang TC. High-salt diet induces gastric epithelial hyperplasia and parietal cell loss, and enhances Helicobacter pylori colonization in C57BL/6 mice. Cancer Res. 1999;59(19):4823-4828.

32. Loh JT, Torres VJ, Cover TL. Regulation of Helicobacter pylori cagA expression in response to salt. Cancer Res. 2007;67(10):4709-4715. doi:10.1158/0008-5472.CAN-06-4746

33. Graham DY, Lu H, Yamaoka Y. African, Asian or Indian enigma, the East Asian Helicobacter pylori: facts or medical myths. J Dig Dis. 2009;10(2):77-84. doi:10.1111/j.1751-2980.2009.00368.x

34. Kumar N, Mukhopadhyay AK, Patra R, et al. Next-generation sequencing and de novo assembly, genome organization, and comparative genomic analyses of the genomes of two Helicobacter pylori isolates from duodenal ulcer patients in India. J Bacteriol. 2012;194(21):5963-5964. doi:10.1128/JB.01371-12

35. Zaidi SF, Muhammad JS, Shahryar S, et al. Anti-inflammatory and cytoprotective effects of selected Pakistani medicinal plants in Helicobacter pylori-infected gastric epithelial cells. J Ethnopharmacol. 2012;141(1):403-410. doi:10.1016/j.jep.2012.03.001

36. Zaidi SF, Yamamoto T, Refaat A, et al. Modulation of activation-induced cytidine deaminase by curcumin in Helicobacter pylori-infected gastric epithelial cells. Helicobacter. 2009;14(6):588-595. doi:10.1111/j.1523-5378.2009.00724.x

37. Varga MG, Butt J, Blot WJ, et al. Racial Differences in Helicobacter pylori CagA Sero-prevalence in a Consortium of Adult Cohorts in the United States. Cancer Epidemiol Biomarkers Prev. 2020;29(10):2084-2092. doi:10.1158/1055-9965.EPI-20-0525

38. Cardenas VM, Graham DY. Smoking and Helicobacter pylori infection in a sample of U.S. adults. Epidemiology. 2005;16(4):586-590. doi:10.1097/01.ede.0000165365.52904.4a

39. Epplein M, Signorello LB, Zheng W, et al. Race, African ancestry, and Helicobacter pylori infection in a low-income United States population. Cancer Epidemiol Biomarkers Prev. 2011;20(5):826-834. doi:10.1158/1055-9965.EPI-10-1258

40. Cho I, Blaser MJ, François F, et al. Helicobacter pylori and overweight status in the United States: data from the Third National Health and Nutrition Examination Survey. Am J Epidemiol. 2005;162(6):579-584. doi:10.1093/aje/kwi237

41. Epplein M, Signorello LB, Zheng W, et al. Race, African ancestry, and Helicobacter pylori infection in a low-income United States population. Cancer Epidemiol Biomarkers Prev. 2011;20(5):826-834. doi:10.1158/1055-9965.EPI-10-1258

42. Parsonnet J, Replogle M, Yang S, Hiatt R. Seroprevalence of CagA-positive strains among Helicobacter pylori-infected, healthy young adults. J Infect Dis. 1997;175(5):1240-1242. doi:10.1086/593680

Data Availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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Volume Title
Proceedings of the 2nd International Conference on Modern Medicine and Global Health
ISBN (Print)
978-1-83558-323-4
ISBN (Online)
978-1-83558-324-1
Published Date
08 March 2024
Series
Theoretical and Natural Science
ISSN (Print)
2753-8818
ISSN (Online)
2753-8826
DOI
10.54254/2753-8818/33/20240891
Copyright
08 March 2024
Open Access
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Copyright © 2023 EWA Publishing. Unless Otherwise Stated