Theoretical and Natural Science

- The Open Access Proceedings Series for Conferences


Theoretical and Natural Science

Vol. 3, 28 April 2023

Open Access | Article

Interventions in Ischemic Stroke Targeting Microglial Activation

Ziqin Wang * 1
1 Division of Natural and Applied Sciences, Duke Kunshan University, Kunshan, Jiangsu, 215316, China

* Author to whom correspondence should be addressed.

Theoretical and Natural Science, Vol. 3, 63-70
Published 28 April 2023. © 2023 The Author(s). Published by EWA Publishing
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation Ziqin Wang. Interventions in Ischemic Stroke Targeting Microglial Activation. TNS (2023) Vol. 3: 63-70. DOI: 10.54254/2753-8818/3/20220179.

Abstract

Ischemic stroke is one of the biggest health concerns nowadays, leading to nonnegligible disability and mortality in its patients. During its pathological development, resident microglia in the central nervous system play a significant role to repair the damage, but may also expand the lesion because of the excessive microglial activation. As a result, microglial activation is considered a potential therapeutic target for ischemic stroke. Since microglia polarized into different phenotypes ranging from M1 to M2 display proinflammatory and neuroprotective functions, regulation of the morpho-functional change of microglia became a further way of intervention in ischemic stroke. This review qualitatively analyses drugs for ischemic stroke that were studied by credible research in the recent ten years in terms of experimental methods, applied animal models, and potential signaling pathways, so as to provide clues for future studies on the fine regulation of microglial activation to treat ischemic stroke.

Keywords

ischemic stroke, microglial activation, microglial polarization, treatment

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Data Availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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Volume Title
Proceedings of the 2nd International Conference on Biological Engineering and Medical Science (ICBioMed 2022), Part I
ISBN (Print)
978-1-915371-25-6
ISBN (Online)
978-1-915371-26-3
Published Date
28 April 2023
Series
Theoretical and Natural Science
ISSN (Print)
2753-8818
ISSN (Online)
2753-8826
DOI
10.54254/2753-8818/3/20220179
Copyright
28 April 2023
Open Access
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Copyright © 2023 EWA Publishing. Unless Otherwise Stated