Theoretical and Natural Science

- The Open Access Proceedings Series for Conferences


Theoretical and Natural Science

Vol. 33, 08 March 2024


Open Access | Article

Diacylglycerol oil on metabolic syndrome: A Review

Yilin Lyu * 1
1 University of California

* Author to whom correspondence should be addressed.

Advances in Humanities Research, Vol. 33, 1-5
Published 08 March 2024. © 2023 The Author(s). Published by EWA Publishing
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation Yilin Lyu. Diacylglycerol oil on metabolic syndrome: A Review. TNS (2024) Vol. 33: 1-5. DOI: 10.54254/2753-8818/33/20240389.

Abstract

The metabolic syndrome is a trait of metabolic disorders that results from the increasing prevalence of obesity. Clinical manifestations include insulin resistance, hyperlipidemia, hyperuricemia, etc. Populations with high morbidity tend to be middle-aged and elder adults. With the advent of an ageing society, the incidence of metabolic syndrome will be higher. Since diacylglycerol (DAG) oil was first introduced in 1999, it has received extensive attention. DAG oils and related products have been distributed in markets in Japan, Europe, and the United States since 2001. This paper will review the effects of the new dietary oil, DAG, on the metabolic syndrome. It is hoped that DAG oil has the ability to replace traditional triacylglycerol (TAG) oil and control the morbidity of metabolic syndrome. This review article collected recent studies, and the results proved that dietary DAG is effective for reducing postprandial blood lipids and blood glucose, managing weight, and ameliorating insulin sensitivity.

Keywords

Diacylglycerol, Metabolic Syndrome, Hyperlipidemia, Obesity, Diabetes Mellitus

References

1. Saklayen, M. G. The Global Epidemic of the Metabolic Syndrome. Current Hypertension Reports, 20(2), 12. (2018).

2. Yanai, H., Tomono, Y., Ito, K., Furutani, N., Yoshida, H., & Tada, N. Diacylglycerol oil for the metabolic syndrome. Nutrition Journal, 6(1), 43. (2007).

3. Eichmann, T. O., & Lass, A. DAG tales: The multiple faces of diacylglycerol — stereochemistry, metabolism, and signaling. Cellular and Molecular Life Sciences, 72(20), 3931–3952. (2015).

4. Lee, Y.-Y., Tang, T.-K., Phuah, E.-T., Tan, C.-P., Wang, Y., Li, Y., Cheong, L.-Z., & Lai, O.-M. Production, safety, health effects and applications of diacylglycerol functional oil in food systems: A review. Critical Reviews in Food Science and Nutrition, 60(15), 2509–2525. (2020).

5. Takase, H. Metabolism of diacylglycerol in humans. Asia Pacific Journal of Clinical Nutrition, 16 Suppl 1, 398–403. (2007).

6. Lai, M., Peng, H., Wu, X., Chen, X., Wang, B., & Su, X. IL-38 in modulating hyperlipidemia and its related cardiovascular diseases. International Immunopharmacology, 108, 108876. (2022).

7. Taguchi, H., Watanabe, H., Onizawa, K., Nagao, T., Gotoh, N., Yasukawa, T., Tsushima, R., Shimasaki, H., & Itakura, H. Double-Blind Controlled Study on the Effects of Dietary Diacylglycerol on Postprandial Serum and Chylomicron Triacylglycerol Responses in Healthy Humans. Journal of the American College of Nutrition, 19(6), 789–796. (2000).

8. Tomonobu, K., Hase, T., & Tokimitsu, I. Dietary diacylglycerol in a typical meal suppresses postprandial increases in serum lipid levels compared with dietary triacylglycerol. Nutrition, 22(2), 128–135. (2006).

9. Fujii, A., Allen, T. J., & Nestel, P. J. A 1,3-diacylglycerol-rich oil induces less atherosclerosis and lowers plasma cholesterol in diabetic apoE-deficient mice. Atherosclerosis, 193(1), 55–61. (2007).

10. Ota, N., Soga, S., Hase, T., Tokimitsu, I., & Murase, T. Dietary Diacylglycerol Induces the Regression of Atherosclerosis in Rabbits ,2. The Journal of Nutrition, 137(5), 1194–1199. (2007).

11. Després, J.-P., & Lemieux, I. Abdominal obesity and metabolic syndrome. Nature, 444(7121), 881–887. (2006).

12. Kawada, T. Food-derived regulatory factors against obesity and metabolic syndrome. Bioscience, Biotechnology, and Biochemistry, 82(4), 547–553. (2018).

13. Maki, K. C., Davidson, M. H., Tsushima, R., Matsuo, N., Tokimitsu, I., Umporowicz, D. M., Dicklin, M. R., Foster, G. S., Ingram, K. A., Anderson, B. D., Frost, S. D., & Bell, M. Consumption of diacylglycerol oil as part of a reduced-energy diet enhances loss of body weight and fat in comparison with consumption of a triacylglycerol control oil. The American Journal of Clinical Nutrition, 76(6), 1230–1236. (2002).

14. Kamphuis, M. M., Mela, D. J., & Westerterp-Plantenga, M. S. Diacylglycerols affect substrate oxidation and appetite in humans. The American Journal of Clinical Nutrition, 77(5), 1133–1139. (2003).

15. Zheng, J. S., Wang, L., Lin, M., Yang, H., & Li, D. BMI status influences the response of insulin sensitivity to diacylglycerol oil in Chinese type 2 diabetic patients. Asia Pacific journal of clinical nutrition, 24(1), 65–72. (2015).

16. Tongcheng, X., Min, J., Xia, L., Bin, Q., Yuan, Z., Wei, L., Aizhen, Z., Lina, L., & Fangling, D. Intake of Diacylglycerols and the Fasting Insulin and Glucose Concentrations: A Meta-Analysis of 5 Randomized Controlled Studies. Journal of the American College of Nutrition, 37(7), 598–604. (2018).

Data Availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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Volume Title
Proceedings of the 2nd International Conference on Modern Medicine and Global Health
ISBN (Print)
978-1-83558-323-4
ISBN (Online)
978-1-83558-324-1
Published Date
08 March 2024
Series
Theoretical and Natural Science
ISSN (Print)
2753-8818
ISSN (Online)
2753-8826
DOI
10.54254/2753-8818/33/20240389
Copyright
© 2023 The Author(s)
Open Access
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Copyright © 2023 EWA Publishing. Unless Otherwise Stated