Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 24, 20 December 2023
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Access | Article
Research on the bidirectional relationships between sleep and parkinson’s disease
* Author to whom correspondence should be addressed.
Abstract
Parkinson’s disease (PD) is the second most prevalent neurodegenerative disease in the world, and among its most common symptoms is sleep disruption. Due to the glymphatic system’s role in removing alpha-synuclein and other substances related to PD pathogenesis, glymphatic dysfunction has been established as a risk factor for PD. Though sleep disturbance is often a symptom of PD, its role in increasing glymphatic clearance has led some researchers to believe that sleep disturbance could also be a risk factor for PD. This review will examine the scientific literature that suggests links between sleep disruption, PD pathology, or glymphatic dysfunction, as well as address some of the limitations in affirming such relationships. According to current research, sleep disruption is a common nonmotor symptom of PD but can also lead to reduced glymphatic function, which in turn reduces alpha-synuclein clearance and advances PD pathogenesis. However, PD development could also impair glymphatic clearance by depolarizing AQP4 channels or reducing sleep duration and quality.
Keywords
sleep, glymphatic system, Parkinson’s disease, alpha-synuclein
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Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the 3rd International Conference on Biological Engineering and Medical Science
- ISBN (Print)
- 978-1-83558-221-3
- ISBN (Online)
- 978-1-83558-222-0
- Published Date
- 20 December 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/24/20231091
- Copyright
- 20 December 2023
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited