Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 22, 20 December 2023
Open
Access | Article
Research on the symptoms, causes, and available treatments of narcolepsy
* Author to whom correspondence should be addressed.
Abstract
The classic tetrad of hypnagogic hallucinations, cataplexy (sudden bilateral loss of muscle tone), excessive daytime sleepiness, and sleep paralysis characterizes narcolepsy, a chronic sleep disorder. Narcolepsy affects 0.05 percent of the population. It lowers the quality of life for those who have it and can prevent them from engaging in certain occupations and pastimes. Therefore, this paper focuses on the symptoms, causes, and available treatments of narcolepsy. Through literature reading and analysis, it can be concluded that narcolepsy with cataplexy is caused by disruptions in signals within the central nervous system and a lack of hypocretins. There is currently no known cure for narcolepsy, and medication along with lifestyle modifications is the basis of therapy. Moreover, several innovative therapies are being created and tested.
Keywords
narcolepsy, cataplexy, hypocretins, deep brain stimulation (DBS), MCH receptor antagonists, cognitive-behavioral therapy
References
1. Health jade team. Narcolepsy. Retrieved from https://healthjade.com/narcolepsy/
2. Gbolagade Sunmaila Akintomide & Hugh Rickards. (2011). Narcolepsy: a review. Neuropsychiatric Disease and Treatment. 513-515
3. Natasha Morales Drissi.(2019). Brain Networks & Dynamics in Narcolepsy. Linköping University medical dissertations. 29-34.
4. Harvard university (February 21, 2018). The Science of Narcolepsy. Retrieved from http://healthysleep.med.harvard.edu/narcolepsy/what-is-narcolepsy/science-of-narcolepsy#:~: text=The%20Science%20of%20Narcolepsy%20Research%20has%20revealed%20that,play%20important%20roles%20in%20the%20development%20of%20narcolepsy.
5. Yuan, L., & Li, D. (2006). Novel central stimulant modafinil. Chinese Journal of New Drugs,15(2),159-160.
6. Liebert, A. D., Bicknell, B. T., Adams, R., & Koenig, K. L. (2014). A review of light therapy for sports injuries. Sports medicine-open,1(1),1-10.
7. Wang, J., Xiao, Q., & Zhang, D. (2018). Diagnosis and treatment of three common sleep-wake disorders in clinical practice. Sichuan Mental Health,31(6),570.
8. Shen, J., Jin, N., & Han, F. (2020). Hypersomnia disorders and mental illness-current situation and progress. (8) 6. Ye, X., & Liu, T. (2018). Study on the influence of unhealthy lifestyle habits on hypersomnia symptoms and regulation. Chinese Journal of Health Nutrition,25(11),5451-5452.
9. Anna, A., Lauren, M., Lou, T,. Sun Yuxian,. Renee M., & Jon, T. (2020). Deep brain stimulation of hypothalamus for narcolepsy-cataplexy in mice.
10. Thomas Scammell, MD. (2021).The Potential of MCHR1 Antagonists in Narcolepsy: Thomas Scammell, MD. Retrieved from https://www.neurologylive.com/view/potential-mchr1-antagonists-narcolepsy-thomas-scammell#:~:text=Benefits%20for%20patients%20with% 20narcolepsy%20included%20the%20fact,who%20have%20not%20had%20results%20with%20other%20medications.
Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the 3rd International Conference on Biological Engineering and Medical Science
- ISBN (Print)
- 978-1-83558-217-6
- ISBN (Online)
- 978-1-83558-218-3
- Published Date
- 20 December 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/22/20230932
- Copyright
- 20 December 2023
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited