Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Vol. 3, 28 April 2023
* Author to whom correspondence should be addressed.
HER2, human epidermal receptor 2(c-erbB-2 gene), is a hot targeted point in various cancer’s targeted therapy. Breast cancer including HER2 positive or negative. HER2 is an oncogenic receptor tyrosine kinase. HER2 gene amplification occurs in some of breast cancers (BCS), resulting in overexpression of the HER2 protein. Compared to the trastuzumab or pertuzumab, the performance of trastuzumab deruxtecan is excellent. Drug resistance is known to be the main cause of failure of tumor chemotherapy. Tumor drug resistance involves various mechanisms, such as those involving decreased intracellular drug concentration, changes of drug target molecules, metabolic detoxification, and imbalance of DNA damage repair function. HER2-positive breast cancer becomes resistant to trastuzumab, thereby blocking effective binding and developing resistance. The significance of this review is to understand the mechanism of drug resistance from molecular and chemotherapy perspectives by studying the structure and overexpression of HER2 protein as predictors, so as to grasp the progress of current targeted drug therapy. Our review starting from HER2 and its targeted therapy gets to the deep insight into the antibody drug conjugates and explores the possible proteins which may become the potential targeted points in future research.
HER2, targeted therapy, antibody-drug conjugates (ADC)
1. MM Moasser. The oncogene HER2: its signaling and transforming functions and its role in human cancer pathogenesis. Oncogene. 2007 Oct 4;26(45):6469-87.
2. V Hart, H Gautrey, J Kirby, A Tyson-Capper. HER2 splice variants in breast cancer: investigating their impact on diagnosis and treatment outcomes. Oncotarget. 2020 Nov 17;11(46):4338-4357.
3. A Appert-Collin, P Hubert, G Crémel, A Bennasroune. Role of ErbB Receptors in Cancer Cell Migration and Invasion. Front Pharmacol. 2015 Nov 24; 6:283.
4. Q Lv, Z Meng, Y Yu, F Jiang, D Guan, C Liang, J Zhou, A Lu, G. Zhang Molecular Mechanisms and Translational Therapies for Human Epidermal Receptor 2 Positive Breast Cancer. Int J Mol Sci. 2016 Dec 14;17(12):2095.
5. Z. Fu, S. Li, S. Han, C. Shi, &, Y. Zhang. Antibody drug conjugate: the "biological missile" for targeted cancer therapy. Signal Transduction and Targeted Therapy, 7(1), 93. (2022)
6. S. Modi, W. Jacot, T. Yamashita, J. Sohn, M. Vidal, E. Tokunaga, J. Tsurutani, N. T. Ueno, A. Prat, Y. S. Chae, K. S. Lee, N. Niikura, Y. H. Park, B. Xu, X. Wang, M. Gil-Gil, W. Li, J. Y. Pierga, S. A. Im, H. Moore … DESTINY-Breast04 Trial Investigators. Trastuzumab Deruxtecan in Previously Treated HER2-Low Advanced Breast Cancer. The New England Journal of Medicine, 387(1), 9–20. (2022)
7. C. H. Chau, P. S. Steeg, & W. D. Figg, Antibody-drug conjugates for cancer. Lancet (London, England), 394(10200), 793–804. (2019)
8. M. Scaltriti, F. Rojo, A. Ocana, J. Anido, M. Guzman, J. Cortes, S. Di Cosimo, X. Matias-Guiu, S. Ramon y Cajal, J. Arribas, & J. Baselga. Expression of p95HER2, a Truncated Form of the HER2 Receptor, and Response to Anti-HER2 Therapies in Breast Cancer. JNCI Journal of the National Cancer Institute, 99(8), 628–638. (2007)
9. Rius Ruiz Irene, Vicario Rocio, Morancho Beatriz et al. p95HER2-T cell bispecific antibody for breast cancer treatment.[J] .Sci Transl Med, 2018.
10. C. A. Dreyer, K. Vander Vorst, S. Free, A Rowson-Hodel, & K. L. Carraway.The role of membrane mucin MUC4 in breast cancer metastasis. Endocrine-Related Cancer, 29(1), R17–R32. (2022)
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