Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 35, 26 April 2024
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Investigating the prevalence and function of the mecA gene and PBP2a protein among Staphylococcus and Mammaliicoccus species
* Author to whom correspondence should be addressed.
Abstract
The mecA gene, an acquired gene encoding an additional penicillin-binding protein (PBP2a) with low affinity to nearly all β-lactams, is associated with the epidemiologically most important mechanism of antibiotic resistance in Staphylococcus aureus. However, apart from S. aureus, the mecA gene and functional PBP2a protein have also been discovered in other staphylococcal or mammalicoccal species. This research uses the Basic Local Alignment Search Tool (BLAST) to gather mecA gene and PBP2a amino acid sequences from multiple bacterial species and analyse the topology, structure, and function of the aligned PBP2a proteins. BLAST analysis indicated that the mecA gene and PBP2a protein sequences are present in several staphylococcal and mammaliicoccal species, and both the structure and function of the PBP2a protein are highly conserved among the species. This research indicates that the mecA gene and PBP2a protein are present and functional in a wide range of staphylococcal and mammaliicoccal species and highlights the high conserveness of the PBP2a protein among those species.
Keywords
Staphylococcus, drug resistance, bioinformatics
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Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the 2nd International Conference on Modern Medicine and Global Health
- ISBN (Print)
- 978-1-83558-395-1
- ISBN (Online)
- 978-1-83558-396-8
- Published Date
- 26 April 2024
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/35/20240926
- Copyright
- 26 April 2024
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited