Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 24, 20 December 2023
Open
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Guvacoline in betel nuts directly binds to and inhibits AChE activity, lowering ACh levels released by neurons
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Abstract
This paper investigates guvacoline, a compound found in betel nut, and its activity on acetylcholine level. Betel nuts are the chewable seeds of plant used in Chinese traditional medicine. It is commonly used all over southern Asia and the east African seaboard, being the fourth most commonly used drug in the world. It is known for being carcinogenic for throat cancer. Immediate symptoms of betel nut chewing indicate activation of the parasympathetic system, in which acetylcholine and acetylcholinesterase is involved. This paper predicts that guvacoline, found in areca nuts, increases free acetylcholine levels released from neurons by allosterically binding to acetylcholinesterase inhibiting it.
Keywords
Traditional Chinese Medicine, Betel Nuts, Acetylcholine
References
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Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the 3rd International Conference on Biological Engineering and Medical Science
- ISBN (Print)
- 978-1-83558-221-3
- ISBN (Online)
- 978-1-83558-222-0
- Published Date
- 20 December 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/24/20231099
- Copyright
- 20 December 2023
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited