Theoretical and Natural Science

- The Open Access Proceedings Series for Conferences


Theoretical and Natural Science

Vol. 24, 20 December 2023


Open Access | Article

Research on the effects of PM2.5 exposure on respiratory and cardiovascular diseases in an aging population

Haocheng Li * 1
1 University Collage London

* Author to whom correspondence should be addressed.

Theoretical and Natural Science, Vol. 24, 117-122
Published 20 December 2023. © 2023 The Author(s). Published by EWA Publishing
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation Haocheng Li. Research on the effects of PM2.5 exposure on respiratory and cardiovascular diseases in an aging population. TNS (2023) Vol. 24: 117-122. DOI: 10.54254/2753-8818/24/20231120.

Abstract

In contemporary times, there is an observable inclination towards the exacerbation of air pollution, which has emerged as a prominent global environmental issue. Among the various factors contributing to this issue, PM2.5 emerges as a key determinant. The geriatric demographic exhibits a heightened vulnerability to respiratory and cardiovascular disorders. This study offers a thorough analysis of the correlation between PM2.5 and human pathology and epidemiology. It also investigates the many pathophysiological pathways that establish a connection between exposure to PM2.5 and the development of respiratory and cardiovascular disorders. The results of this study suggest that PM2.5 has a substantial impact on the occurrence and fatality rates of several common illnesses within the senior demographic. Furthermore, this paper offers recommendations for potential public health interventions intended to alleviate the adverse effects of this avoidable determinant on the development of diseases and death rates.

Keywords

aging people, respiratory disorders, cardiovascular disorders, pathophysiological pathways, public health

References

1. World Health Organization. (2014). 7 million premature deaths annually linked to air pollut-ion. World Health Organization. https://www.who.int/news/item/25-03-2014-7-million-pre-mature-deaths-annually-linked-to-air-pollution

2. GBD 2013 Risk Factors Collaborators. (2015). Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013. Lancet (London, England), 386(10010), 2287.

3. World Health Organization. (2013). Health Effects of Particulate Matter: Policy implications for countries in eastern Europe, Caucasus and central Asia.

4. Bell, M. L., & Davis, D. L. (2001). Reassessment of the lethal London fog of 1952: novel indicators of acute and chronic consequences of acute exposure to air pollution. Environmental health perspectives, 109(suppl 3), 389-394.

5. Maciejewska, K. (2020). Short-term impact of PM2. 5, PM10, and PMc on mortality and morbidity in the agglomeration of Warsaw, Poland. Air Quality, Atmosphere & Health, 13(6), 659-672.

6. Alcántara, V., & Padilla, E. (2009). Input–output subsystems and pollution: An application to the service sector and CO2 emissions in Spain. Ecological Economics, 68(3), 905-914.

7. Ji, X., Yao, Y., & Long, X. (2018). What causes PM2. 5 pollution? Cross-economy empirical analysis from socioeconomic perspective. Energy Policy, 119, 458-472.

8. Seguel, R. (2009). Estimations of primary and secondary organic carbon formation in PM2. 5 aerosols of Santiago City, Chile. Atmospheric Environment, 43(13), 2125-2131.

9. Sandradewi, J., Prévôt, A. S., Szidat, S., Perron, N., Alfarra, M. R., Lanz, V. A., ... & Baltensperger, U. R. S. (2008). Using aerosol light absorption measurements for the quantitative determination of wood burning and traffic emission contributions to particulate matter. Environmental science & technology, 42(9), 3316-3323.

10. Xing, Y. F., Xu, Y. H., Shi, M. H., & Lian, Y. X. (2016). The impact of PM2. 5 on the human respiratory system. Journal of thoracic disease, 8(1), E69.

11. Samoli, E., Analitis, A., Touloumi, G., Schwartz, J., Anderson, H. R., Sunyer, J., ... & Katsouyanni, K. (2005). Estimating the exposure–response relationships between particulate matter and mortality within the APHEA multicity project. Environmental health perspectives, 113(1), 88-95.

12. World Health Organization. (2013). Cardiovascular diseases (CVDs): fact sheet no. 317. Media centre. World Health Organization, 20(1), 3.

13. Brook, R. D., Rajagopalan, S., Pope III, C. A., Brook, J. R., Bhatnagar, A., Diez-Roux, A. V., ... & Kaufman, J. D. (2010). Particulate matter air pollution and cardiovascular disease: an update to the scientific statement from the American Heart Association. Circulation, 121(21), 2331-2378.

14. Sacks, J. D., Stanek, L. W., Luben, T. J., Johns, D. O., Buckley, B. J., Brown, J. S., & Ross, M. (2011). Particulate matter–induced health effects: who is susceptible?. Environmental health perspectives, 119(4), 446-454.

15. Ostro, B., Broadwin, R., Green, S., Feng, W. Y., & Lipsett, M. (2006). Fine particulate air pollution and mortality in nine California counties: results from CALFINE. Environmental health perspectives, 114(1), 29-33.

16. Donaldson, K., Beswick, P. H., & Gilmour, P. S. (1996). Free radical activity associated with the surface of particles: a unifying factor in determining biological activity?. Toxicology letters, 88(1-3), 293-298.

17. Greenwell, L. L., Moreno, T., Jones, T. P., & Richards, R. J. (2002). Particle-induced oxidative damage is ameliorated by pulmonary antioxidants. Free Radical Biology and Medicine, 32(9), 898-905.

18. Valavanidis, 1. A., Fiotakis, K., Bakeas, E., & Vlahogianni, T. (2005). Electron paramagnetic resonance study of the generation of reactive oxygen species catalysed by transition metals and quinoid redox cycling by inhalable ambient particulate matter. Redox Report, 10(1), 37-51.

19. Mehta, M., Chen, L. C., Gordon, T., Rom, W., & Tang, M. S. (2008). Particulate matter inhibits DNA repair and enhances mutagenesis. Mutation Research/Genetic Toxicology and Environmental Mutagenesis, 657(2), 116-121.

20. Kim, Y. K., Jung, J. S., Lee, S. H., & Kim, Y. W. (1997). Effects of antioxidants and Ca2+ in cisplatin-induced cell injury in rabbit renal cortical slices. Toxicology and applied pharmacology, 146(2), 261-269.

21. Xing, W. J., Kong, F. J., Li, G. W., Qiao, K., Zhang, W. H., Zhang, L., ... & Xu, C. Q. (2011). Calcium‐sensing receptors induce apoptosis during simulated ischaemia–reperfusion in Buffalo rat liver cells. Clinical and Experimental Pharmacology and Physiology, 38(9), 605-612.

22. Brown, D. M., Donaldson, K., Borm, P. J., Schins, R. P., Dehnhardt, M., Gilmour, P., ... & Stone, V. (2004). Calcium and ROS-mediated activation of transcription factors and TNF-α cytokine gene expression in macrophages exposed to ultrafine particles. American Journal of Physiology-Lung Cellular and Molecular Physiology, 286(2), L344-L353.

23. Sigaud, S., Goldsmith, C. A. W., Zhou, H., Yang, Z., Fedulov, A., Imrich, A., & Kobzik, L. (2007). Air pollution particles diminish bacterial clearance in the primed lungs of mice. Toxicology and applied pharmacology, 223(1), 1-9.

24. Gripenbäck, S., Lundgren, L., Eklund, A., Liden, C., Skare, L., Tornling, G., & Grunewald, J. (2005). Accumulation of eosinophils and T-lymphocytes in the lungs after exposure to pinewood dust. European Respiratory Journal, 25(1), 118-124.

25. Gordon, S. (2003). Alternative activation of macrophages. Nature reviews immunology, 3(1), 23-35.

26. Veronesi, B., Oortgiesen, M., Carter, J. D., & Devlin, R. B. (1999). Particulate matter initiates inflammatory cytokine release by activation of capsaicin and acid receptors in a human bronchial epithelial cell line. Toxicology and applied pharmacology, 154(1), 106-115.

27. Martinelli, N., Olivieri, O., & Girelli, D. (2013). Air particulate matter and cardiovascular disease: a narrative review. European journal of internal medicine, 24(4), 295-302.

28. Rückerl, R., Greven, S., Ljungman, P., Aalto, P., Antoniades, C., Bellander, T., ... & Peters, A. (2007). Air pollution and inflammation (interleukin-6, C-reactive protein, fibrinogen) in myocardial infarction survivors. Environmental health perspectives, 115(7), 1072-1080.

29. Pope 3rd, C. A., Hansen, M. L., Long, R. W., Nielsen, K. R., Eatough, N. L., Wilson, W. E., & Eatough, D. J. (2004). Ambient particulate air pollution, heart rate variability, and blood markers of inflammation in a panel of elderly subjects. Environmental health perspectives, 112(3), 339-345.

30. Becker, S., Dailey, L., Soukup, J. M., Silbajoris, R., & Devlin, R. B. (2005). TLR-2 is involved in airway epithelial cell response to air pollution particles. Toxicology and applied pharmacology, 203(1), 45-52.

31. Zhong, J., Colicino, E., Lin, X., Mehta, A., Kloog, I., Zanobetti, A., ... & Baccarelli, A. A. (2015). Cardiac autonomic dysfunction: particulate air pollution effects are modulated by epigenetic immunoregulation of toll‐like receptor 2 and dietary flavonoid intake. Journal of the American Heart Association, 4(1), e001423.

32. Seaton, A., Godden, D., MacNee, W., & Donaldson, K. (1995). Particulate air pollution and acute health effects. The lancet, 345(8943), 176-178.

33. Bonzini, M., Tripodi, A., Artoni, A., Tarantini, L., Marinelli, B., Bertazzi, P. A., ... & Baccarelli, A. (2010). Effects of inhalable particulate matter on blood coagulation. Journal of Thrombosis and Haemostasis, 8(4), 662-668.

34. Peters, A., Fröhlich, M., Döring, A., Immervoll, T., Wichmann, H. E., Hutchinson, W. L., ... & Koenig, W. (2001). Particulate air pollution is associated with an acute phase response in men. Results from the MONICA–Augsburg Study. European heart journal, 22(14), 1198-1204.

35. Rhoden, C. R., Wellenius, G. A., Ghelfi, E., Lawrence, J., & González-Flecha, B. (2005). PM-induced cardiac oxidative stress and dysfunction are mediated by autonomic stimulation. Biochimica et Biophysica Acta (BBA)-General Subjects, 1725(3), 305-313.

36. Liao, D., Duan, Y., Whitsel, E. A., Zheng, Z. J., Heiss, G., Chinchilli, V. M., & Lin, H. M. (2004). Association of higher levels of ambient criteria pollutants with impaired cardiac autonomic control: a population-based study. American journal of epidemiology, 159(8), 768-777.

37. Devlin, R. B., Ghio, A. J., Kehrl, H., Sanders, G., & Cascio, W. (2003). Elderly humans exposed to concentrated air pollution particles have decreased heart rate variability. European Respiratory Journal, 21(40 suppl), 76s-80s.

38. Xu, M. M., Jia, Y. P., Li, G. X., Liu, L. Q., Mo, Y. Z., Jin, X. B., & Pan, X. C. (2013). Relationship between ambient fine particles and ventricular repolarization changes and heart rate variability of elderly people with heart disease in Beijing, China. Biomedical and Environmental Sciences, 26(8), 629-637.

39. Park, S. K., O’Neill, M. S., Vokonas, P. S., Sparrow, D., & Schwartz, J. (2005). Effects of air pollution on heart rate variability: the VA normative aging study. Environmental health perspectives, 113(3), 304-309.

40. Niu, J., Liberda, E. N., Qu, S., Guo, X., Li, X., Zhang, J., ... & Qu, Q. (2013). The role of metal components in the cardiovascular effects of PM2. 5. PloS one, 8(12), e83782.

41. Newby, D. E., Mannucci, P. M., Tell, G. S., Baccarelli, A. A., Brook, R. D., Donaldson, K., ... & ESC Working Group on Thrombosis. (2015). European Association for Cardiovascular Prevention and Rehabilitation; ESC Heart Failure Association. Expert position paper on air pollution and cardiovascular disease. Eur Heart J, 36(2), 83-93b.

Data Availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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Volume Title
Proceedings of the 3rd International Conference on Biological Engineering and Medical Science
ISBN (Print)
978-1-83558-221-3
ISBN (Online)
978-1-83558-222-0
Published Date
20 December 2023
Series
Theoretical and Natural Science
ISSN (Print)
2753-8818
ISSN (Online)
2753-8826
DOI
10.54254/2753-8818/24/20231120
Copyright
20 December 2023
Open Access
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Copyright © 2023 EWA Publishing. Unless Otherwise Stated