Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 32, 06 March 2024
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The role of Wnt5a in aging-related diseases
* Author to whom correspondence should be addressed.
Abstract
Wnt is a family of glycoproteins that are essential signalling molecules during development, but its overexpression in adulthood leads to ageing of the organism, and in particular, the expression of Wnt5a is an important factor in the development of diseases such as atherosclerosis, osteoarthritis and tendon ageing. In atherosclerosis, patients serum levels of Wnt5a is elevated and Wnt5a is linked to β-catenin-independent signaling pathways which is related to the expression of inflammatory genes and the advancement of inflammation. Osteoarthritis’ one character is the demolition of cartilage. In this disease, the expression model of Wnt5a will change from canonical to non-canonical, and this kind of model actives chondrocyte catabolism. Tendons can repair and regenerate themselves through tendon stem cells (TSPC). Tendon senescence is inextricably linked to the senescence of TSPC, overexpressing of Wnt5a affects tendon stem cells thus leads to tendon aging.The aim of this paper is to analyse the role of Wnt5a in the development of these diseases and suggest effective treatments for them.
Keywords
Wnt5a, atherosclerosis, osteoarthritis, tendon aging
References
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Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the 2nd International Conference on Modern Medicine and Global Health
- ISBN (Print)
- 978-1-83558-321-0
- ISBN (Online)
- 978-1-83558-322-7
- Published Date
- 06 March 2024
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/32/20240810
- Copyright
- 06 March 2024
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited