Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 32, 06 March 2024
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Transmissibility of phosphorylated α-synuclein in the brain of Parkinson’s Disease model mice
* Author to whom correspondence should be addressed.
Abstract
Parkinson’s disease (PD) is a chronic neurodegenerative disease. The pathogenesis of PD is the misfolding and accumulation of the alpha-synuclein protein leading to degeneration and death of dopaminergic neurons in the Substantia nigra. This study focuses on the transmissibility of phosphorylated α-synuclein in the brain of PD model mice. In this study, DAT-IRES-Cre+/-/LSL-SNCA-GFP+/- mice was used as a model, and experimental techniques including frozen section of mouse brain, immunohistochemical staining, and confocal microscopy were used to investigate the transmission of α-synuclein as well as Lewy bodies, which are abnormal aggregates of α-synuclein, in the mouse brain. We conclude that phosphorylated α-synuclein (pSyn) can propagate from the dorsal striatum to the Substantia Nigra Pars Compacta (SNc) through the dopaminergic pathway, resulting in the formation of Lewy bodies in dopaminergic neurons in the SNc, causing neuronal death and thus leading to the pathogenesis of Parkinson’s disease.
Keywords
Parkinson’s disease, dopaminergic neurons, phosphorylated α-synuclein, Lewy bodies
References
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Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the 2nd International Conference on Modern Medicine and Global Health
- ISBN (Print)
- 978-1-83558-321-0
- ISBN (Online)
- 978-1-83558-322-7
- Published Date
- 06 March 2024
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/32/20240803
- Copyright
- 06 March 2024
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited