Theoretical and Natural Science

- The Open Access Proceedings Series for Conferences

Theoretical and Natural Science

Vol. 6, 03 August 2023

Open Access | Article

1-MHC as a target for cancer treatments

Qingxuan Gai 1 , Yibo Quan 2 , Hoi-Wa Tsang * 3 , Ziyang Wang 4
1 China Medical University
2 Basis International Park Lane Harbour
3 The Affiliated International School (YHV) of Shenzhen University
4 Walnut High School

* Author to whom correspondence should be addressed.

Theoretical and Natural Science, Vol. 6, 445-449
Published 03 August 2023. © 2023 The Author(s). Published by EWA Publishing
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation Qingxuan Gai, Yibo Quan, Hoi-Wa Tsang, Ziyang Wang. 1-MHC as a target for cancer treatments. TNS (2023) Vol. 6: 445-449. DOI: 10.54254/2753-8818/6/20230295.


Class-1 Major Histocompatibility Complex (MHC) molecules plays an important role in the immune system by exposing antigens to T cells for identification and destruction. Cancer cells often evade the immune system by downregulating MHC expression, avoiding detection from immune cells. Therefore, Class-1 MHC molecules are potential targets for cancer treatments. Recent studies have shown that increasing MHC expression in cancer cells can enhance T cell recognition and enhance the efficacy of immunotherapies, such as checkpoint inhibitors and adoptive cell transfer therapies. In addition, some therapeutic approaches are aimed at directly targeting Class-1 MHC molecules. This paper summarizes the mechanism of MHC expression, the current status of cancer treatments, relevant research status of class-1 MHC as a target in cancer therapy, and how this technique can be improved. These findings highlight the potential of Class-1 MHC as a promising target for cancer treatment, and further research is needed to fully exploit this target for the benefit of cancer patients.


Class-1 MHC, immunotherapy, cancer


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Data Availability

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Volume Title
Proceedings of the International Conference on Modern Medicine and Global Health (ICMMGH 2023)
ISBN (Print)
ISBN (Online)
Published Date
03 August 2023
Theoretical and Natural Science
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ISSN (Online)
03 August 2023
Open Access
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Copyright © 2023 EWA Publishing. Unless Otherwise Stated