Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 29, 16 January 2024
Open
Access | Article
Cyclin D1 in various cancers: Mechanisms and clinical implications
* Author to whom correspondence should be addressed.
Abstract
Gastrointestinal cancers, including esophageal, gastric, hepatic, pancreatic, and colorectal malignancies, present a significant global health challenge. Their distinct characteristics characterized by abnormal cell proliferation, invasive behavior, and tumor formation make them highly aggressive and detrimental to human health. These diseases often lead to malnutrition, organ failure, and obstruction. Cyclin D1 protein is a critical regulator of cell cycle progression and an essential marker for comprehending the complex landscape of cancer biology. This research provides an in-depth exploration of gastrointestinal cancers by shedding light on their adverse effects on the human body while emphasizing the critical role played by cyclin D1 within this challenging disease context. Extensively studied in colorectal cancer as well as esophageal squamous cell carcinoma (ESCC), gastric cancer, and pancreatic cancer contexts. Cyclin D1 emerges as a key player. Specifically, in cases of colorectal cancer, overexpression of cyclin D1 is frequently linked to aggressive tumor behavior brought on by APC gene mutations and abnormal Wnt signalling pathway activation. Esophageal cancer patients especially those with ESCC frequently exhibit elevated levels of Cyclin D1 indicating poor prognosis. A similar trend is observed in gastric cancer where increased expression of cyclin D1 is linked to disease severity.
Keywords
gastrointestinal cancers, esophageal cancer, gastric cancer, cyclin D1
References
1. Murphy N, Jenab M, Gunter M J. 2018 Nature Reviews Gastroenterology & Hepatology 15(11) 659-670
2. O’Connor M J, Thakar T, Nicolae C M, et al. 2021 Oncogene 40(30) 4872-4883
3. Montalto F I, De Amicis F. 2020 Cells 9(12) 2648
4. Huang F L, Yu S J. 2018 Asian journal of surgery 41(3) 210-215
5. Smyth E C, Nilsson M, Grabsch H I, et al. 2020 The Lancet 396(10251) 635-648
6. Dekker E, Tanis P J, Vleugels J L A, et al. 2019 Lancet 394(10207)1467-1480
7. Thanikachalam K, Khan G. 2019 Nutrients 11(1) 164
8. Weitz J, Koch M, Debus J, et al. 2005 Lancet 365(9454) 153-165
9. Tchakarska G, Sola B. 2020 Cell cycle 19(2) 163-178
10. Kontomanolis E N, Koutras A, Syllaios A, et al. 2021 J. BU ON Off. J. Balk. Union Oncol. 26 1723-1734
Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the 2nd International Conference on Modern Medicine and Global Health
- ISBN (Print)
- 978-1-83558-279-4
- ISBN (Online)
- 978-1-83558-280-0
- Published Date
- 16 January 2024
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/29/20240752
- Copyright
- 16 January 2024
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited