Theoretical and Natural Science

- The Open Access Proceedings Series for Conferences


Theoretical and Natural Science

Vol. 32, 06 March 2024


Open Access | Article

Research progress on circular RNAs

ZHANG Yang * 1 , Qingsong Li 2 , Wei qiangman 3
1 China institute of sport science
2 Peking University Third Hospital Cancer Center
3 China institute of sport science

* Author to whom correspondence should be addressed.

Theoretical and Natural Science, Vol. 32, 114-118
Published 06 March 2024. © 2023 The Author(s). Published by EWA Publishing
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation ZHANG Yang, Qingsong Li, Wei qiangman. Research progress on circular RNAs. TNS (2024) Vol. 32: 114-118. DOI: 10.54254/2753-8818/32/20240809.

Abstract

Circular RNAs (circRNAs) as a new type of non-coding RNA are special circular molecules with covalently closed 3’ end and 5’ end. Although they were previously discovered as errors in RNA splicing process and drew little attention, their unique properties, powerful functions and as potential disease biomarker are being increasingly acknowledged by scientists. Recently, circRNAs have become a hotspot in scientific field. In this review, we describe the biogenesis, classification, biological characteristics, functions and association with human disease of circRNAs. The emergence of circRNAs will provide a new way to study the pathogenesis of human disease, such as nervous system disease, tumor and ageing.

Keywords

circular RNA, biological function, nervous system disease, tumor, ageing

References

1. Sanger H L 1976 Viroids are single-stranded covalently closed circular RNA molecules existing as highly base-paired rod-like structures J. Proceedings of the National Academy of Sciences of the United S’tates of America, 73(11):3852-3856.

2. Hsu M and Cocaprado M 1979 Electron microscopic evidence for the circular form of RNA in the cytoplasm of eukaryotic cells J. Nature, 280(5720):339-40.

3. Kos A, Dijkema R, Arnberg AC, van der Meide P H and Schellekens H 1986 The hepatitis delta (δ) virus possesses a circular RNA J. Nature, 280(5720):339-40.

4. Hansen T B, Jensen T I, Clausen B H, Bramsen J B, Finsen B, Damgaard C K and Kjems J 2013 Natural RNA circles function as efficient microRNA sponges J. Nature, 495(7441):384-388.

5. Memczak S, et al 2013 Circular RNAs are a large class of animal RNAs with regulatory potency J. Nature, 495(7441):333.

6. Capel B, Swain A, Nicolis S, Hacker A, Walter M, Koopman P, Goodfellow P and Lovell-Badge R1993 Circular transcripts of the testis-determining gene Sry in adult mouse testis J. Cell, 73(5):1019-1030.

7. Danan M, Schwartz S, Edelheit S and Sorek R 2011 Transcriptome-wide discovery of circular RNAs in Archaea J. Nucleic Acids Research, 40(7):3131-3142.

8. Salzman J, Gawad C, Wang PL, Lacayo N and Brown P O 2012 Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell Types J. Plos One, 7(2):e30733.

9. Cocquerelle C, Mascrez B, Hétuin D and Bailleul B 1993 Mis-splicing yields circular RNA molecules J. Faseb Journal Official Publication of the Federation of American Societies for Experimental Biology, 7(1):155.

10. Jeck W R, Sorrentino J A, Wang K, Slevin M K, Burd C E, Liu J, Marzluff W F and Sharpless N E 2013 Circular RNAs are abundant, conserved, and associated with ALU repeats J. RNA, 9(2):141-57.

11. Jeck W R and Sharpless N E 2014 Detecting and characterizing circular RNAs J. Nature Biotechnology, 32(5):453.

12. Memczak S, et al 2013 Circular RNAs are a large class of animal RNAs with regulatory potency J. Nature, 495(7441):333.

13. Qi-er L I, Guo-liang Y E and Guo J M 2014 Long Non-coding RNA,a New Star Sparkling in Cancer Molecular Diagnosis J. Chinese Journal of Biochemistry & Molecular Biology, 2014.

14. Li z, et al 2015 Exon-intron circular RNAs regulate transcription in the nucleus J. Nature Structural & Molecular Biology, 22(3):256.

15. Zhang X O, Wang H B, Zhang Y, Lu X, Chen L L and Yang L 2014 Complementary sequence-mediated exon circularization J. Cell, 159(1):134-147.

16. Conn S J, Pillman K A, Toubia J, Conn V M, Salmanidis M, Phillips C A, Roslan S, Schreiber A W, Gregory P A and Goodall G J 2015 The RNA binding protein quaking regulates formation of circRNAs J. Cell, 160(6):1125-1134.

17. Chen L L and Yang L 2015 Regulation of circRNA biogenesis J. Rna Biology, 12(4):381.

18. Hoffmann S 2014 A multi-split mapping algorithm for circular RNA, splicing, trans-splicing and fusion detection J. Genome Biology, 15(2):1-11.

19. Wilusz J 2015 Circular RNA and Splicing: Skip Happens J. Journal of Molecular Biology, 427(15):2411.

20. Liang D and Wilusz J E 2014 Short intronic repeat sequences facilitate circular RNA production J. Genes & Development, 28(20):2233-2247.

21. Lasda E and Parker R 2014 Circular RNAs: diversity of form and function J. Rna-a Publication of the Rna Society, 20(12):1829.

22. Ashwal-Fluss R, Meyer M, Pamudurti N R, Ivanov A, Bartok O, Hanan M, Evantal N, Memczak S, Rajewsky N and Kadener S 2014 circRNA Biogenesis Competes with Pre-mRNA Splicing J. Molecular Cell, 56(1):55-66.

23. Kelly S, Greenman C, Cook P R and Papantonis A 2015 Exon Skipping Is Correlated with Exon Circularization J. Journal of Molecular Biology, 427(15):2414-2417.

24. Salzman J, Chen R E, Olsen M N, Wang P L and Brown P O 2013 Cell-Type Specific Features of Circular RNA Expression J. Plos Genetics, 9(9):e1003777.

25. Militello G, Weirick T, John D, Döring C, Dimmeler S and Uchida S 2017 Screening and validation of lncRNAs and circRNAs as miRNA sponges J. Briefings in Bioinformatics, 8(5):780-788.

26. Panda A C, Grammatikakis I, Kim K M, De S, Martindale J L, Munk R, Yang X, Abdelmohsen K and Gorospe M 2016 Identification of senescence-associated circular RNAs (SAC-RNAs) reveals senescence suppressor CircPVT1 J. Nucleic Acids Res, 2016, 34(21):6233-46.

27. Abdelmohsen K, et al 2017 Identification of HuR target circular RNAs uncovers suppression of PABPN1 translation by CircPABPN1 J. RNA Biol, 14(3):361-369.

28. Kos A, Dijkema R, Arnberg A C, van der Meide P H and Schellekens H 1986 The hepatitis delta (δ) virus possesses a circular RNA J. Nature, 323(6088):558.

29. AbouHaidar M G, Venkataraman S, Golshani A, Liu B and Ahmad T 2014 Novel coding, translation, and gene expression of a replicating covalently closed circular RNA of 220 nt J. Proceedings of the National Academy of Sciences, 11(40):14542-14547.

Data Availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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Volume Title
Proceedings of the 2nd International Conference on Modern Medicine and Global Health
ISBN (Print)
978-1-83558-321-0
ISBN (Online)
978-1-83558-322-7
Published Date
06 March 2024
Series
Theoretical and Natural Science
ISSN (Print)
2753-8818
ISSN (Online)
2753-8826
DOI
10.54254/2753-8818/32/20240809
Copyright
06 March 2024
Open Access
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Copyright © 2023 EWA Publishing. Unless Otherwise Stated