Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 16, 04 December 2023
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Research on the correlation between toxic aggregation in brain and cell-cell fusion caused by SARS-CoV-2 infection
* Author to whom correspondence should be addressed.
Abstract
Since the outbreak of the COVID-19 pandemic, much research has been done to understand SARS-CoV-2's and COVID-19, the disease it cause. The pathway that the virus relies on to infect cells is through binding of the viral protein to the ACE2 receptor on the surface of host cells. After replication, the virus most often exits the cell by lysosomal exocytosis, which releases the virus into the extracellular space, and the cycle repeats. However, cell-cell fusion caused by SARS-CoV-2 can promote viral spread by fusing neighboring cells to form syncytia, leading to the infection of neighboring cells. One of the major concerns regarding SARS-CoV-2 is the neuroinvasive potential the virus exhibits. Cell-cell fusion is observed in neuronal cells as well, potentially compromising the overall integrity of neuronal activities. Thus, in this research proposal, cell-cell fusion and its impact on brains will be investigated by assaying its influence on protein aggregations in brains. The proposal plans to apply both brain organoids and animal models for assessment. Hypothetically, once cell-cell fusion and formation of protein is observed in brain tissue samples, more information can be revealed towards comprehending the mechanisms of SARS-CoV-2 activities during infection.
Keywords
SARS-Cov-2, Brain, Cell-Cell Fusion, Neurodegenerative Disease, Protein Aggregation
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Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the 2nd International Conference on Modern Medicine and Global Health
- ISBN (Print)
- 978-1-83558-195-7
- ISBN (Online)
- 978-1-83558-196-4
- Published Date
- 04 December 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/16/20240541
- Copyright
- 04 December 2023
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited