Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 22, 20 December 2023
Open
Access | Article
Analysis on endoplasmic reticulum stress in the cancer cells
* Author to whom correspondence should be addressed.
Abstract
One consequence of being in a low-oxygen environment is endoplasmic reticulum (ER) stress, and the unfolded protein response (UPR) is one mechanism to alleviate this condition. In recent years, numerous researchers have proposed employing the UPR in cancer therapy. Apoptosis of cancer cells can be induced by targeting the UPR in a variety of ways. This can be triggered by a number of drugs, some of which induce ER stress while others suppress the unfolded protein response and hence cause death in cancer cells. Through a literature review and analysis, this paper will discuss ER stress in a hypoxic microenvironment, the role of the unfolded protein response in cancer cells, and the therapeutic targeting of the unfolded protein response's protective pathways in the treatment of cancer.
Keywords
endoplasmic reticulum stress, cancer cells, hypoxic tumor microenvironment
References
1. Xingmin Jing et al. Mol Cancer. Role of hypoxia in cancer therapy by regulating the tumor microenvironment, Mol Cancer. P1-2, (2019).
2. Xi Chen et al. Nat Rev Cancer. FebEndoplasmic reticulum stress signals in the tumour and its microenvironment. Nat Rev Cancer. P6, (2021).
3. Zhou Jiang et al. Front Cell Dev Biol. Transmissible Endoplasmic Reticulum Stress: A Novel Perspective on Tumor Immunity, Front Cell Dev Biol. P101-102, (2020).
4. Cubillos-Ruiz JR, Bettigole SE, Glimcher LH. Tumorigenic and Immunosuppressive Effects of Endoplasmic Reticulum Stress in Cancer. Cell. Feb 9;168(4):692-706, (2017).
5. Chen X, Cubillos-Ruiz JR. Endoplasmic reticulum stress signals in the tumour and its microenvironment. Nat Rev Cancer. 21(2):71-88, (2021).
Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. Authors who publish this series agree to the following terms:
1. Authors retain copyright and grant the series right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this series.
2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the series's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this series.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See Open Access Instruction).
- Volume Title
- Proceedings of the 3rd International Conference on Biological Engineering and Medical Science
- ISBN (Print)
- 978-1-83558-217-6
- ISBN (Online)
- 978-1-83558-218-3
- Published Date
- 20 December 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/22/20230912
- Copyright
- 20 December 2023
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited