Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 8, 13 November 2023
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Research and prospect of inclusion complexes of dexibuprofen β-cyclodextrin
* Author to whom correspondence should be addressed.
Abstract
Dexibuprofen is an over-the-counter drug often used to relieve pain and reduce fever. However, dexibuprofen is less soluble in the gastrointestinal tract, resulting in a slower rate of absorption. In order to enhance the bioavailability, researchers have devised inclusion complexes including dexibuprofen and cyclodextrin. β-cyclodextrin is a cyclic molecule characterized by its annular configuration and possesses a distinctive void structure that enables the entrapment of other molecules via an enveloping mechanism, ultimately leading to the formation of a robust inclusion complex. The incorporation of dexibuprofen into an inclusion complex resulted in enhanced stability, higher aqueous solubility, and improved oral bioavailability. Furthermore, the incorporation of the inclusion complex can potentially mitigate the gastric mucosa irritation caused by dexibuprofen and minimize the gastrointestinal tract's unfavorable effects via the inclusion combination. The inclusion complex of dexibuprofen and β-cyclodextrin is a form of drug with improved solubility and bioavailability that has broad application prospects to provide more effective pain relief and fever treatment. This study focuses on the investigation of the preparation and identification of dexibuprofen clathrate through a comprehensive analysis of existing literature. The primary objective is to determine the most effective inclusion technique for dexibuprofen based on considerations of yield and clathrate rate. Additionally, the research article examined the methodology for the formulation of clathrate into dispersible tablets, along with an initial investigation into the pharmacokinetics of these tablets in rat models.
Keywords
Dexibuprofen, Β-Cyclodextrin, Inclusion Complex, Dispersion Tablet, Pharmacokinetics
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Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the 2nd International Conference on Modern Medicine and Global Health
- ISBN (Print)
- 978-1-83558-111-7
- ISBN (Online)
- 978-1-83558-112-4
- Published Date
- 13 November 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/8/20240359
- Copyright
- 13 November 2023
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited