Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 29, 16 January 2024
Open
Access | Article
L-theanine mechanism and application in the treatment of breast cancer
* Author to whom correspondence should be addressed.
Abstract
Breast cancer has been recognized as the leading cancer worldwide and is one of the most common diseases among women, with an incidence rate of up to 7.7%. The pathogenesis of breast cancer can be categorized into congenital and acquired factors, including epigenetics and mutations. The occurrence of breast cancer is closely related to acquired factors such as environment, emotions, and diet. Numerous studies have demonstrated that L-theanine in tea can intervene in the growth and spread of breast cancer cells, thus playing a role in the treatment and prevention of breast cancer. This article provides an overview of the current research on the prevention and treatment of breast cancer using L-theanine, and also prospects the future development and application of L-theanine.
Keywords
Breast cancer, L-theanine, Epigenetics, Treatment
References
1. Sharma, R., Global, regional, national burden of breast cancer in 185 countries: evidence from GLOBOCAN 2018. Breast Cancer Research and Treatment, 2021. 187(2).
2. An, L., et al., L-Theanine regulates glutamine metabolism and immune function by binding to cannabinoid receptor 1. Food & function, 2021.
3. Shuna, C., et al., L-Theanine and Immunity: A Review. Molecules (Basel, Switzerland), 2023. 28(9).
4. Tan, J. F., Lin, Z. & Li, L., Safety toxicological study of theanine complex preparation. Food Science, 2011. 32(19): pp. 262-267..
5. Kuo, C., et al., Recent Advances in Therapeutic Modalities Against Breast Cancer-Related Lymphedema: Future Epigenetic Landscape. Lymphatic research and biology, 2023.
6. Hong-yu, S., et al., Integration of bioinformatics and machine learning strategies identifies APM-related gene signatures to predict clinical outcomes and therapeutic responses for breast cancer patients. Neoplasia, 2023. 45.
7. Katsutoshi, H., et al., Clear Cell Squamous Cell Carcinoma of the Maxillary Gingiva Associated with PIK3CA and HRAS Mutations: Report of a Case and Literature Review. Head and neck pathology, 2023.
8. Sun, Q. The Research Progress of Cancer Immunotherapy. in The Research Progress of Cancer Immunotherapy. 2022.Chengdu, Sichuan, China.
9. G, S.T., et al., B-cells and regulatory T-cells in the microenvironment of HER2+ breast cancer are associated with decreased survival: a real-world analysis of women with HER2+ metastatic breast cancer. Breast cancer research : BCR, 2023. 25(1).
10. Liu, W., et al. Indirect Carcinoma-stromal Interaction Enhances Invasion of Both Fibroblast and Tumor Cells on a Microfluidic Co-culture Device. in Indirect Carcinoma-stromal Interaction Enhances Invasion of Both Fibroblast and Tumor Cells on a Microfluidic Co-culture Device. 2016.Sanya, Hainan, China.
11. Kristyn, G., et al., Impact of rare and multiple concurrent gene fusions on diagnostic DNA methylation classifier in brain tumors. Molecular cancer research : MCR, 2023.
12. Yixuan, M., et al., Mitochondrial DNA methylation is a predictor of immunotherapy response and prognosis in breast cancer: scRNA-seq and bulk-seq data insights. Frontiers in immunology, 2023. 14.
13. YH, W., et al., Inhibition of A2AR gene methylation alleviates white matter lesions in chronic cerebral hypoperfusion rats. European review for medical and pharmacological sciences, 2022. 26(8).
14. Christina, S. and G.S. A, Studies in CRISPR-generated Mediterranean G6PD variant rats reveal G6PD orchestrates genome-wide DNA methylation and gene expression in vascular wall. bioRxiv : the preprint server for biology, 2023.
15. Saeed, M., et al., Green tea ( Camellia sinensis ) and l -theanine: Medicinal values and beneficial applications in humans—A comprehensive review. Biomedicine & Pharmacotherapy, 2017. 95.
16. Pereira, J.G., et al., Breast Cancer Brain Metastases: Implementation and Characterization of a Mouse Model Relying on Malignant Cells Inoculation in the Carotid Artery. Cells, 2023. 12(16).
17. Yu, R. Application of different analysis methods to detect telomerase activity in cancer cells. in Application of different analysis methods to detect telomerase activity in cancer cells. 2023. Xiamen, Fujian, China.
18. Bi, A., et al., l -Theanine attenuates neointimal hyperplasia via suppression of vascular smooth muscle cell phenotypic modulation. The Journal of Nutritional Biochemistry, 2020. 82(prepublish).
19. Magdalena, G. and M. Barbara, Pro- and Antiangiogenic Factors in Gliomas: Implications for Novel Therapeutic Possibilities. International Journal of Molecular Sciences, 2021. 22(11).
20. Hongyuan, S., et al., Cuprous oxide nanoparticles inhibit angiogenesis via down regulation of VEGFR2 expression. Nanoscale, 2014. 6(6).
21. Ling, L., et al., L-Theanine attenuates heat stress-induced proteotoxicity and alterations in carbohydrate and lipid metabolism via heat shock factor 1. Food & function, 2023.
Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. Authors who publish this series agree to the following terms:
1. Authors retain copyright and grant the series right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this series.
2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the series's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this series.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See Open Access Instruction).
- Volume Title
- Proceedings of the 2nd International Conference on Modern Medicine and Global Health
- ISBN (Print)
- 978-1-83558-279-4
- ISBN (Online)
- 978-1-83558-280-0
- Published Date
- 16 January 2024
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/29/20240762
- Copyright
- 16 January 2024
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited