Theoretical and Natural Science

- The Open Access Proceedings Series for Conferences

Theoretical and Natural Science

Vol. 35, 10 July 2024

Open Access | Article

The discovery of osimertinib (AZD9291) for the treatment of lung cancer and its chemistry

Victor Li * 1
1 University High School

* Author to whom correspondence should be addressed.

Theoretical and Natural Science, Vol. 35, 225-236
Published 10 July 2024. © 2023 The Author(s). Published by EWA Publishing
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation Victor Li. The discovery of osimertinib (AZD9291) for the treatment of lung cancer and its chemistry. TNS (2024) Vol. 35: 225-236. DOI: 10.54254/2753-8818/35/20240515.


Inhibitors of the epidermal growth factor receptor (EGFR) have been approved as drugs to treat patients with non-small-cell lung cancer (NSCLC). While these medications exhibit good clinical efficacy, a lot of patients acquire treatment resistance due to T790M mutation, causing the disease to advance. Furthermore, these medicines may hit the EGFR wild-type receptor, leading to adverse effects. In this publication, we present the discovery of the medication osimertinib (AZD9291), a mutant-selective agent. The T790M resistant mutant and EGFR sensitizing (or activating, EGFRm+) mutant are both irreversibly inhibited. In addition, it possesses high selectivity to the receptor's wild-type form.


osimertinib (AZD9291), epidermal growth factor receptor (EGFR), tyrosine kinase inhibitors, drug resistance, anticancer


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Data Availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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Volume Title
Proceedings of the 2nd International Conference on Modern Medicine and Global Health
ISBN (Print)
ISBN (Online)
Published Date
10 July 2024
Theoretical and Natural Science
ISSN (Print)
ISSN (Online)
10 July 2024
Open Access
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Copyright © 2023 EWA Publishing. Unless Otherwise Stated