Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 35, 10 July 2024
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The discovery of osimertinib (AZD9291) for the treatment of lung cancer and its chemistry
* Author to whom correspondence should be addressed.
Abstract
Inhibitors of the epidermal growth factor receptor (EGFR) have been approved as drugs to treat patients with non-small-cell lung cancer (NSCLC). While these medications exhibit good clinical efficacy, a lot of patients acquire treatment resistance due to T790M mutation, causing the disease to advance. Furthermore, these medicines may hit the EGFR wild-type receptor, leading to adverse effects. In this publication, we present the discovery of the medication osimertinib (AZD9291), a mutant-selective agent. The T790M resistant mutant and EGFR sensitizing (or activating, EGFRm+) mutant are both irreversibly inhibited. In addition, it possesses high selectivity to the receptor's wild-type form.
Keywords
osimertinib (AZD9291), epidermal growth factor receptor (EGFR), tyrosine kinase inhibitors, drug resistance, anticancer
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Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the 2nd International Conference on Modern Medicine and Global Health
- ISBN (Print)
- 978-1-83558-395-1
- ISBN (Online)
- 978-1-83558-396-8
- Published Date
- 10 July 2024
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/35/20240515
- Copyright
- 10 July 2024
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited