Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 3, 28 April 2023
Open
Access | Article
Analysis of Autoimmune Disease: Mechanism, Genetic Susceptibility and Environmental Factors
* Author to whom correspondence should be addressed.
Abstract
This article discussed three aspects of autoimmune disease, including mechanism, genetic susceptibility, and environmental factors. Molecular mimicry and dual T cell receptor are two systems of the mechanism. Genetic susceptibility is depending on the environment and polymorphism. Lastly, the environmental factors rely on latitude, industrial development, and gender bias. This article provides a review of autoimmune disease which can help the researchers to further understand the basic information.
Keywords
Immune system, Autoimmune disease (AID), Dual T cell receptors (TCR)
References
1. Cusick, M. F., Libbey, J. E., & Fujinami, R. S. Molecular Mimicry as a Mechanism of Autoimmune Disease. Clinical Reviews in Allergy &Immunology. 2012; 42(1):102–111.
2. Bodis G, Toth V, Schwarting A. Role of human leukocyte antigens (HLA) in autoimmune diseases. Rheumatology and Therapy. 2018;5(1):5–20.
3. Jörg, S., Grohme, D. A., Erzler, M., Binsfeld, M., Haghikia, A., Müller, D. N., Linker, R. A., & Kleinewietfeld, M. Environmental factors in autoimmune diseases and their role in multiple sclerosis. Cellular and Molecular Life Sciences. 2016;73(24):4611–4622.
4. Dornmair, K., Goebels, N., Weltzien, H. U., Wekerle, H., & Hohlfeld, R. T-cell-mediated autoimmunity: novel techniques to characterize autoreactive T-cell receptors. The American journal of pathology. 2003;163(4):1215–1226.
5. Schuldt, N. J., & Binstadt, B. A. Dual TCR T Cells: Identity Crisis or Multitaskers? Journal of immunology (Baltimore, Md.: 1950). 2019;202(3): 637–644.
6. Pugliese, A. Autoreactive T cells in type 1 diabetes. Journal of Clinical Investigation. 2017;127(8): 2881–2891.
7. Clark M, Kroger CJ, Ke Q, Tisch RM. The role of T cell receptor signaling in the development of type 1 diabetes. Frontiers in Immunology. 2021;11.
8. Kandola, A. What are some potential warning signs of type 1 diabetes in children? [Internet]. Medical News Today. 2021 [cited 2022 Mar 24]. Avalible from https://www.medicalnewstoday.com/articles/type-1-diabetes-in-children#definition
9. Gomez-Tourino, I., Kamra, Y., Baptista, R., Lorenc, A., & Peakman, M. T cell receptor β-chains display abnormal shortening and repertoire sharing in type 1 diabetes. Nature Communications. 2017;8(1).
10. Coelho, S. Spondyloarthritis: Types, symptoms, treatment, and more [Internet]. Medical News Today. 2021 [cited 2022 Mar 24]. Available from: https://www.medicalnewstoday.com/articles/spondyloarthritis
11. Miyadera, H., & Tokunaga, K. Associations of human leukocyte antigens with autoimmune diseases: challenges in identifying the mechanism. Journal of Human Genetics. 2015;60(11): 697–702.
12. Patel, A. Women are 3 times more likely to get MS than men — here’s what we know [Internet]. Global News. 2020 [cited 2022 Mar 24]. Available from https://globalnews.ca/news/4197032/women-3-times-ms/
13. Brazier, Y. Multiple sclerosis: What you need to know [Internet]. Medical News Today. 2021 [cited 2022 Mar 24]. Avalible from https://www.medicalnewstoday.com/articles/37556#what-is-ms
14. Dean M. The vitamin deficiency linked to autoimmune disorders [Internet]. PsyBlog. 2022 [cited 2022 Mar 24]. Available from: https://www.spring.org.uk/2022/03/vitamin-autoimmunedisorders.php
15. Barrell, A. How to get more vitamin D from the sun [Internet]. Medical News Today. 2021 [cited 2022 Mar 24]. Available from: https://www.medicalnewstoday.com/articles/326167#boosting-vitamin-d
16. Fugger, L., Jensen, L. T., & Rossjohn, J. Challenges, Progress, and Prospects of Developing Therapies to Treat Autoimmune Diseases. Cell. 2020;181(1): 63–80.
17. May, B. Autoimmune diseases: All you need to know [Internet]. Medical News Today. 2020 [cited 2022 Mar 24]. Available from https://www.medicalnewstoday.com/articles/311852#common-types
18. DocWire News Featured Reading. The immunogenetics of systemic sclerosis [Internet]. Docwire News. 2022 [cited 2022 Mar 25]. Available from: https://www.docwirenews.com/conditioncenter/multiple-sclerosis-knowledge-hub/the-immunogenetics-of-systemic-sclerosis-3/
19. McNamee, D. New hope for lupus screening and treatment [Internet]. Medical News Today. 2014 [cited 2022 Mar 24]. Available from https://www.medicalnewstoday.com/articles/271456
Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. Authors who publish this series agree to the following terms:
1. Authors retain copyright and grant the series right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this series.
2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the series's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this series.
3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See Open Access Instruction).
- Volume Title
- Proceedings of the 2nd International Conference on Biological Engineering and Medical Science (ICBioMed 2022), Part I
- ISBN (Print)
- 978-1-915371-25-6
- ISBN (Online)
- 978-1-915371-26-3
- Published Date
- 28 April 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/3/20220174
- Copyright
- 28 April 2023
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited