Theoretical and Natural Science

- The Open Access Proceedings Series for Conferences

Theoretical and Natural Science

Vol. 6, 03 August 2023

Open Access | Article

Lysosomal proton pump: its role in SARS-CoV-2’s egress and future therapeutic application

Yuhan Chen * 1
1 Beijing National Day School

* Author to whom correspondence should be addressed.

Theoretical and Natural Science, Vol. 6, 364-370
Published 03 August 2023. © 2023 The Author(s). Published by EWA Publishing
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation Yuhan Chen. Lysosomal proton pump: its role in SARS-CoV-2’s egress and future therapeutic application. TNS (2023) Vol. 6: 364-370. DOI: 10.54254/2753-8818/6/20230287.


The coronavirus SARS-CoV-2 is currently spreading throughout the world. The severity of the situation has increased efforts to create efficient prevention and treatment strategies. SARS-CoV-2 has been the subject of numerous experiments, and as a result, scientists now understand it better. Usually, the virus exits the cell through exocytosis. However, SARS-CoV-2 utilizes deacidified lysosomes as a means to egress from the infected cell.This proposal shows a deep understanding of lysosomal viral secretion and elaborates on the impact of the lysosomal proton pump, which functions to regulate the pH value of the endo-lysosomal environment, on lysosome functioning. Experiment are proposed to test the ability of a lysosomal proton pump inhibitor to impede the egress of the SARS-CoV-2 virus and analyze its potential application in a therapeutic target.


SARS-CoV-2. deacidified lysosomes, lysosomal viral secretion, lysosomal proton pump


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Data Availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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Volume Title
Proceedings of the International Conference on Modern Medicine and Global Health (ICMMGH 2023)
ISBN (Print)
ISBN (Online)
Published Date
03 August 2023
Theoretical and Natural Science
ISSN (Print)
ISSN (Online)
03 August 2023
Open Access
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Copyright © 2023 EWA Publishing. Unless Otherwise Stated