Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 17, 04 December 2023
Open
Access | Article
Flavonoids and the gut microbiota: A promising frontier for colorectal cancer prevention and intervention
* Author to whom correspondence should be addressed.
Abstract
Colorectal cancer (CRC) is a formidable global health challenge, with increasing incidence rates and significant mortality. Flavonoids, known for their antioxidant properties, a class of polyphenolic compounds found in various dietary sources, exert multifaceted effects on gut microbiota composition, short-chain fatty acids (SCFAs) production, inflammation mitigation, and gut barrier enhancement. Moreover, they demonstrate promise in countering DNA damage induced by microbial toxins and modulating metabolic processes. Animal studies and clinical trials revealed changes in gut microbiota composition in CRC. However, the translational application of flavonoids to treat CRC through modifying gut microbiota requires further research. This review paper delves into the intricate relationship between flavonoids, and gut microbiota, with a particular focus on their potential in CRC prevention. This paper discusses the complex mechanisms through which flavonoids influence CRC development and highlights their potential in shaping dietary strategies for cancer prevention. In the midst of the rising CRC burden, flavonoids offer a hopeful link between dietary choices and improved health outcomes, paving the way for a healthier, cancer-free future.
Keywords
Flavonoids, Gut Microbiota, Colorectal Cancer
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Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the 2nd International Conference on Modern Medicine and Global Health
- ISBN (Print)
- 978-1-83558-197-1
- ISBN (Online)
- 978-1-83558-198-8
- Published Date
- 04 December 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/17/20240627
- Copyright
- 04 December 2023
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited