Theoretical and Natural Science

- The Open Access Proceedings Series for Conferences

Theoretical and Natural Science

Vol. 6, 03 August 2023

Open Access | Article

G proteins: introduction of its history, structure, function, and drug development

Tianyi Bi 1 , Pengyu Wei * 2
1 Northeast Forestry University
2 Maple leaf school

* Author to whom correspondence should be addressed.

Theoretical and Natural Science, Vol. 6, 311-315
Published 03 August 2023. © 2023 The Author(s). Published by EWA Publishing
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation Tianyi Bi, Pengyu Wei. G proteins: introduction of its history, structure, function, and drug development. TNS (2023) Vol. 6: 311-315. DOI: 10.54254/2753-8818/6/20230265.


G protein-coupled receptor can be written in GPCR, it has a big great family and this species include 800 human genes, it become the important part of human body. Although each species has their own unique skills, it can make different kind of medicine that can save human’s life. And then there's the G-protein-coupled receptor mechanism. The GPCR desensitization regulator - arrestin was further analyzed, and researchers discovered that GPCRs could be activated not only through the G-protein-dependent pathway but also through the non-G-protein-dependent pathway, known as the -inhibitor pathway, to control the ingestion and desensitization throughout vivo and even start a new wave of signal transduction. The development of G-protein-coupled receptor drugs followed. GPCR is strongly associated to pathological conditions and has an essential function in cell signal transmission. More than 40% of the medicines on the market today target GPCR, which is the reached a high point family of pharmacological targets. The intracellular effector proteins (G proteins, etc.) that are activated by the GPCR play an important role in the regulation of its physiological function.


G protein-coupled receptor (GPCR), medicines, signal transduction, pharmacological targets, intracellular effector proteins


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Data Availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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Volume Title
Proceedings of the International Conference on Modern Medicine and Global Health (ICMMGH 2023)
ISBN (Print)
ISBN (Online)
Published Date
03 August 2023
Theoretical and Natural Science
ISSN (Print)
ISSN (Online)
03 August 2023
Open Access
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Copyright © 2023 EWA Publishing. Unless Otherwise Stated