Theoretical and Natural Science

- The Open Access Proceedings Series for Conferences


Theoretical and Natural Science

Vol. 33, 08 March 2024


Open Access | Article

The mechanism and efficiency of mRNA-based dendritic cell immunotherapy

Jiayi Wang * 1
1 St. Columba's College

* Author to whom correspondence should be addressed.

Theoretical and Natural Science, Vol. 33, 20-23
Published 08 March 2024. © 2023 The Author(s). Published by EWA Publishing
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation Jiayi Wang. The mechanism and efficiency of mRNA-based dendritic cell immunotherapy. TNS (2024) Vol. 33: 20-23. DOI: 10.54254/2753-8818/33/20240543.

Abstract

In the recent years, the mentions of immunotherapy has become more and more frequent. What emerged along with it are the various types of immunotherapies. This essay includes an introduction to cancer and tumor with the definition, epidemiology, etiology, statistics such as curability regarding types, gender, and race and typical treatments of cancer along with how the immune system functions when targeting tumor cells and how they could potentially disfunction when deceived by tumor cells for example through immune editing. Then, leading on to the main topic to this recent and innovative treatment— immunotherapy. This essay emphasizes on two different types of immunotherapy which are dendritic cell therapy, and messenger RNA vaccine discussing their mechanism as separate treatments. Afterwards, I’ll proceed to discuss the combination of the two which is known as dendritic cell based mRNA vaccine which is a form of mRNA vaccine and it’s own mechanism, advantages, efficiency and current limitations in the conclusion.

Keywords

Cancer, immunotherapy, dendritic cells, mRNA vaccine

References

1. Stoppler, Melissa C. "Why Is Breast Cancer More Common in Females Than Males ? "MedicineNet, 10 May 2017, www.medicinenet.com/breast_cancer_in_males_and_ females/ask.htm. Accessed 20 Sept. 2023.

2. Komen, Susan G. "Race and Ethnicity." Susan G. Komen®, 27 July 2022, www.komen.org/breast-cancer/risk-factor/race-ethnicity/. Accessed 20 Sept. 2023.

3. Taylor, Ashley P. "The 10 Deadliest Cancers, and Why There's No Cure." Livescience.com, 21 Sept. 2022, www.livescience.com/11041-10-deadliest-cancers-cure.html. Accessed 20 Sept. 2023.

4. Sabado, Rachel et al, Dendritic cell-based immunotherapy, nature, Cell Research (2016) 1-22, Doi: 10.1038/cr.2016.157. last accessed 20 AUGUST. 2023

5. Lorentzen, Cathrine Lund et al, Clinical advances and ongoing trials of mRNA vaccines for cancer treatment, Lancet oncology, October 7, 2022 Doi: 10.1016/S1470-2045(22)00372-2. Last accessed 20 AUGUST. 2023

6. Gilboa, Eli et al, immunotherapy of cancer with dendritic-cell-based vaccines, cancer immune immunother (1998)45:82-87, Doi: 10.1007/s002620050465 last accessed 20 September. 2023

Data Availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

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Volume Title
Proceedings of the 2nd International Conference on Modern Medicine and Global Health
ISBN (Print)
978-1-83558-323-4
ISBN (Online)
978-1-83558-324-1
Published Date
08 March 2024
Series
Theoretical and Natural Science
ISSN (Print)
2753-8818
ISSN (Online)
2753-8826
DOI
10.54254/2753-8818/33/20240543
Copyright
08 March 2024
Open Access
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Copyright © 2023 EWA Publishing. Unless Otherwise Stated