The Role of A High-Carbohydrates Diet on Alzheimer’s Disease

. Brain diseases, like majority illnesses, are influenced in some way by nutrition. Alzheimer’s disease, which is characterized by brain cell deaths and memory loss, is significantly influenced by sugar intake. The frequency, quantity, and type of carbohydrates can influence AD development and outcomes. Whether highly processed or not, carbohydrate-rich foods influence AD. This paper discusses how a high-carbohydrate diet increases the chances of AD development and aggravation. General introduction to carbohydrate diets and the etiology of AD are explained. Subsequently, details on nonmodified and modified AD risk factors are addressed. The present paper moreover examines the imperative relationship between AD and high-carbohydrates diets. Particularly, the paper elucidates how: carbohydrate-rich diets impair cognitive function; how the diet aggravates AD ramifications. Furthermore, the paper evaluates how high-carbohydrates diets: alter AD biomarkers; interact with age to influence AD; and how carbohydrate-rich diets prevent brain cell growth and repair. The report addresses the prevailing therapeutic methods that can be employed to prevent and manage Alzheimer’s disease. Such interventions include the use of caffeine to significantly less cognitive deterioration in AD patients is addressed. Other interventions addressed regard how ketogenic diets can effectively aid with AD prevention; minimal sugar consumption; and how physical activities can aid AD prevention and management. Besides, AD-derived diseases are also addressed. The paper finds that high-carbohydrate diets should be avoided, and healthier lifestyle practices are integral for AD prevention and management.


Introduction
The popular adage, "you are what you eat" has been proven time and again to be true in matters of health and wellbeing. This includes physical and mental health conditions. Particularly, Alzheimer's excessive amount of sugar intake, negatively affects brain health and aggravates brain inflammation by releasing "pro-inflammatory cytokines that promote nitric oxide, facilitating anxious states in humans and rodents" [11]. A high carbohydrate diet causes low-density lipoprotein cholesterol to surge, which leads to more C-reactive protein. This has been shown to cause inflammation [12]. In general, since AD is linked is characterized by brain inflammation and a high-carbohydrate diet is proved to activate brain inflammation, intaking excessive sugar and glucose in a long-term diet can promote the progression of AD. Among AD patients, reliance on high-carbohydrates diets has the potential to influence gene expression and AD outcome. Butler et al.'s research on rats with AD reveals the need for concern about carbohydrates' permanent effects. The study finds that people who consume highly processed carbohydrate foods risk exacerbating their hippocampus' cognitive inability. Further, the older an individual is, the greater the extent to which inflammatory gene is expressed in the DNA. Refined carbohydrates, however, do not cause neuroinflammatory gene expression and diminished mental abilities among the young. These patterns of gene expression gravely affect memory functions that are regulated by the amygdala as well as the hippocampus parts of the brain [13]. Based on this revelation, the side effects of high carbohydrate diets are definitely affirmed to present a danger to AD patients' health. Knowing that extreme refinement of carbohydrates predisposes elderly persons to permanent gene alteration at the fundamental level underpins the need for research that seeks ways to overturn such effects. Other studies have also related the level of carbohydrates diet to glycemic regulating biomarkers. For example, Yang, Eun Ju, et al.'s work on the same establishes that consuming diets with low-carbohydrates content heightens the quantity and rate at which basal insulin is secreted in the body of disease-free adults and that such individuals exhibit a high level of Serum C-peptide [14]. This means that limiting the amount of carbohydrate intake ensures that a person's glycemic biomarkers are not impeded -an aspect that is beneficial for healthy blood glucose regulation. Otherwise, high carbohydrate diets would diminish Serum C-peptide hence worsening insulin secretion and resultantly exacerbating predisposition to AD and worsening cognitive performance.
Glycation, a process that impairs serum proteins when they are exposed to high glucose levels, results in the emergence of a group diversified from terminally misfolded proteins known as advanced glycation end products (AGEs). High amounts of AGEs are found in the brains of AD patients, and these AGEs aid in amyloid plaques formation [15]. The oxidative stress speeds up this formation. The effects of AGEs and intermediate glycated isoforms on the body are varied. They have the potential to cause the buildup of harmful amyloid fibrils or to trigger the irreversible cross-linking of extracellular matrix proteins, but more importantly, they are in charge of activating the AGE-receptor for AGE (RAGE) signaling pathway, which in turn causes a variety of cellular reactions, such as apoptosis and inflammation [16]. The early stage of the Alzheimer's cascade may involve glycation of ApoE, and the increased affinity of ApoE-4 may significantly increase the risk of developing AD. Also, glycation may be an early sign of AD because it has been demonstrated that the Aβ plaque is one of the characteristics of AD that associated with AGEs and that these damaged proteins can be found even in micro-neural slices where Aβ is absent [17].
On the other hand, high carbohydrate diet also affects insulin and glucose metabolism, contributing to the deterioration of AD. How is carbohydrate related to glucose metabolism impairment? One way that deduced glucose metabolism can speed up AD is that it leads to dysfunctional mitochondria which ultimately causes the blockade of energy sources. In addition, impaired glucose metabolism negatively impacts brain health through metabolic diseases and property change of essential proteins like tau.
Besides, some evidence also shows that in rats, treating by high sucrose diet, found learning impairment while spontaneous locomotor activity remained unchanged [18].

High-carbohydrates diet affects cognitive function
Consumption of diets that are high in carbohydrate diminish cognitive ability and in the process cause and worsen Alzheimer's disease symptoms. Empirical studies by Beilharz Maniam & Morris on the relationship between participants' source of energy affirm that consumption of large quantities of carbohydrates causes and worsen AD. Particularly, people who rely on carbohydrates for their dietary sugars often experience brain damage in the hippocampus area, the brain portion which is responsible for memory. Simple sugars from carbohydrates are posited to have some of the most dangerous effects on the functioning of the hippocampus. These effects are asserted to be worse than the ramifications caused by proteins and fats on cognitive abilities [19]. Humans' ability to remember short-term or episodic events: like recollecting the food that is already taken, the ability to react to feelings of hunger, and satisfaction from food already eaten are all performed by the hippocampus. The brain's inability to sense such episodic events and signals thus implies that one would not remember their feeding behaviors and would thus consume food in undesirable patterns, in excessive quantity, and without knowing when to stop feeding [19]. As FIGURE 1 demonstrates, the main source of hippocampal and memory damage, the carbohydrate-sourced simple sugars, would over-accumulate in the body and worsen the same symptoms without the person knowing. Consequently, the dangerous pattern would aggravate AD and related health complications like type 2 diabetes. Large doses of dietary carbohydrates lead to the [19,20]. Generally, the main challenge posed by carbohydrate-rich diets on cognitive function is the strain caused by simple sugars upon the hippocampus.

Relationship between a high-carbohydrate diet with age, and AD
Besides, the quantity and type of carbohydrates consumed by a person influence their AD outcomes in relation to their age. Empirical studies have linked the effect of high carbohydrate diets on whether the same would cause AD in younger or older people. For example, it is noted that although high carbohydrate diets affect the elderly more, it does not impair memory challenges in children in any significant way. However, when young adults and children consume glycemia-rich carbohydrates, their memory capabilities deteriorate significantly [19]. Another study affirms that feeding on high-carbohydrate foods worsens glycemia levels in older adults whose genotype is the "apolipoprotein E (APOE) έ4 allele" and this subsequently leads to serious memory and attention deficit among Alzheimer's Disease patients [20].
When individuals eat foods high in carbohydrates, the body breaks down the carbohydrates into simple sugars. The high sugar content subsequently accumulates in the blood -this in turn leads to hyperglycemia. Hyperglycemia otherwise referred to as extreme blood glucose saturation, is worse among older adults who are suffering from AD, especially when the consumed carbohydrates are extremely processed. The study establishes that while older adults who are non-carriers of APOE έ4 suffer from worse verbal memory due to high carbohydrate intake APOE έ4 carriers with AD suffer most from declined ability to pay attention due to carbohydrate-rich diets [20]. It is thus apparent that genetic aspects such as alleles interact with age and resultantly influence the kind of cognitive impairment that becomes more pronounced following a carbohydrate-rich diet. It can be noted that in as much as carbohydrate-rich foods negatively impacts AD symptoms, the amount of glycemia and whether the carbohydrate is processed, as well as the subject's age, can be used to regulate AD onset and symptoms.
6. Carbohydrate-rich diets prevent brain repair by cyclically destroy the brain Although the brain is naturally self-repairing, carbohydrate-rich diets prevent the brain from achieving these activities, hence predisposing affected people to AD, and also worsening the risk of irreparable brain damage and the worst AD outcome. According to Yeh et al.'s study, foods high in sucrose limit the brain's ability to produce leptin hormone for brain cell repair and growth [22]. Since leptin is responsible for the creation, growth, and protection of brain cells, reduced brain signaling for leptin secretion tends to impede leptin production in the nervous system. As a consequence, a low amount of leptin hormone reduces the brain's capacity to naturally facilitate memory areas of the brain from developing, growing, repairing, and/or protecting itself from degenerating [23]. FIGURE 2 simplifies the relationship between leptin and AD.

Figure 2.
The relationship between sugar intake, leptin action, and AD risk factors [23].
Taking high-carbohydrate meals increases sucrose in the body, -this consequently paves way for AD aggravation due to limited leptin secretion and function. Insel, Turner, & Ross underpin that carbohydrates exist mainly as either simple or complex sugars. The authors further distinguish simple sugars as monosaccharides and disaccharides. Among the complex sugars is sucrose. The disaccharides, which are basically a combination of two bonded monosaccharides, include sucrose and are found in table sugar, and honey, among other carbohydrates [24]. The categories of carbohydrate-derived sugars, their sources, and examples are summarized in FIGURE 3 and 4. Besides the knowledge that consuming high-carbohydrate meals is harmful to individuals suffering from Alzheimer's Disease, it is even much more crucial to be wary of the worst outcome that could happen over time to the vulnerability of the brain cells to permanent destruction following sucrose-induced leptin non-secretion and ineffectiveness.

Low carbohydrate diet-ketogenic diets
A high carbohydrate diet has a strong relationship with increasing the risk of AD. Hence, a low carbohydrate diet, such as a ketogenic diet, can be helpful in the healing of AD. The ketogenic diet (KD) is a diet that consists of very low carbohydrate intake and high fat intake, which is adequate to increase the generation of ketone bodies. In particular, the KD has also been shown to have prominent effects in preventing and alleviating cognitive impairment. 11 human and 11 animal studies were included in a translational review that supplementation with ketogenic diets significantly improved overall cognition, ability of memorizing information, and executive function in humans and improved cognitive function in mouse models of AD and aging animals [25]. Moreover, one of the recent research projects suggests that a KD containing 20 g of medium-chain triglycerides (MCTs) improved their memory when they are working, more sensitive to the visual senses, and feel free when exchanging task in non-demented older individuals [26]. Additionally, mild to moderate AD patients experienced substantial to take a turn for the better logical memory tests and processing speed compared to baseline scores at 8 and 12 weeks after starting the MCT-based nutritional ketogenic formulation [27]. Moreover, one of the symptoms of AD is restraining brain glucose metabolism. A ketogenic diet can produce ketone body (KB); it can supply brain glucose which helps heal AD and KB can rise the efficiency of mitochondria, which issue in an improve in the capacity of brain's normal reliance on glucose [28] . In some experiments, from the comparison of the effect of using standard diet (SD) comprising of high carbohydrate and low fat and a ketogenic diet (KD) consisting of the low carbohydrate & high saturated fat diet to mice, more evidence shows that feeding KD can reduce around 25% of total brain Aβ levels [29]. Nevertheless, although the ketogenic diet brings numerous benefits to healing AD, some points also need to be noticed. TABLE 1 below shows the effects of eating the low carbohydrate diet or extremely low carbohydrate in the long term, it could cause amounts of diseases and harm such as lack of variety of nutrients. Table 1. Advantages and disadvantages of a low-carb diet [30].

Merits Pitfalls
Helps short term weight loss Lack of some items of nutrients from the diet.
Helps glycemic control in people with diabetes Might related to higher risk of mortality.
Halitosis, nausea, weariness, an inability to exercise, and an electrolyte and volume imbalance are among the symptoms of ketosis. Potentially harmful long-term health effects, including gout, kidney stones, and bone loss.

Effects of caffeine in AD
A purine alkaloid known as caffeine (1,3,7-trimethylxanthine), caffeine is always found in coffee beans, tea, cola, and nuts. It exhibits variable favorability in different age groups, with young people favoring cola more than others [31]. Caffeine consumption in several studies reduced cognitive decline and memory deficits in the APPswe transgenic mice model and displayed neuroprotective action [31]. Caffeine's neuroprotective properties and decreased Aβproduction were caused by the suppression of BACE-1 and γ-secretase, reduced caspase-3 activity, cAMP/PKA (cyclic adenosine monophosphate/phosphokinase A) signaling pathway activation, and stimulation of cAMP response element-binding protein (CREB) phosphorylation in the striatum all work together to prevent neuronal cell death [31]. The trial, however, also demonstrates that caffeine consumption in pregnant rats may increase the likelihood of developing AD in its early stages [31]. Additionally, cilostazol (CSZ) and caffeine normalized the buildup of Amyloid beta (Aβ-42) and phosphorylated tau protein (p-tau) positive cells in the brain of T2D mice. Additionally, some data suggests that CSZ + caffeine will have a more significant impact than either drug alone [32]. Generally, caffeine can improve cognitive function, which is helpful for AD patients, but pregnant women should reduce taking caffeine to prevent the risk of suffering AD.

Sugar regulation carbs and AD
Regulating the amount, pattern, and frequency of dietary sugars is a great way to avoid developing Alzheimer's disease. Similar to previous studies that relate simple sugars to cognitive functions, Morris & Burns, and Akimoto et al. agree that minimizing the proportion of dietary sugar is imperative for AD prevention [33,34]. The authors demonstrate this by affirming that on while excessive sugar consumption leads to overweight and subsequent development of type II diabetes. They augment the assertion that since AD often arises from insulin secretion failure and failed blood sugar regulation in T2D patients, preventing diabetes before it happens definitely eliminates a situation where the brain's homeostatic activities impair. Lee et al. concur with this view, and they explain that repeated consumption of diabetes-causing foods, like processed sugars, over time induces hyperglycemia and consequently AD [35]. Beilharz, Maniam & Morris, and Hawkins et al. explain that it is vital to limit the amount of sugar consumed since this would minimize the calories one derives from dietary sugar [19,20]. This would prevent inflammation of the central nervous system's neurons and therefore ensure that the hippocampus and surrounding brain areas that are responsible for proper hippocampal activities remain healthy. Consequently, AD would not occur. Particularly, simple sugars, especially sucrose, must be avoided so as to prevent brain swelling and the related effect on negative biomarker effects [21]. As previously explained by Marwarha & Ghribi, the greater the quantity of sugar intake, the less the brain's ability to signal for leptin release and function [23]. As such, minimizing the proportion of sugar ingestion assures insulin production and function in maintaining blood glucose. This way, no excessive blood sugar would bar leptin release [23]. The outcome would be that brain cell production, protection from damage, and healing would be sustained at par. The long-term outcome is that AD would not materialize in the first place.

Conclusion
AD is a devastating neurodegenerative and sporadic disease. Types of diet, such as high-carbohydrate diet, aging, head injuries and genetic are the major reasons that researchers have found influenced on AD. Although carbohydrates are the main source of energy that can fuel people's brain and central nervous system, excessive intake of carbohydrates will have negative impact on human body, especially on brain and nervous system. In spite of considerable progress in the understanding of how the disease occurs at the molecular level, no effective therapeutic approaches are yet available. The studies that involve humans still have some restrictions. Studies of long-term case control are needed to see how high-carbohydrate diets influence on AD shown by the biomarkers, such as Aβ-42 plaques, t-Tau, and p-Tau. Some current research has focused on regulating the processing of APP proteins and correcting the imbalance between Aβ production and clearance. It's still controversial that the main event that triggers the development of AD is the consumption of a high-carbohydrate diet. Collectively, a high-carbohydrate diet has either directly or indirectly negative effect on AD. According to this theory, relatively simple preventive measures like cutting back on starchy carbohydrates and increasing essential fatty acids intake might be helpful especially at the prodromal stage. More research is needed to demonstrate the effect of the HC diet on AD. Moreover, caffeine and other therapies like ketone body therapy may also be useful. It is hoped that more future studies will focus on the role of diet in AD and effective therapeutic prevention or treatment will discover in the future.