Theoretical and Natural Science
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Theoretical and Natural Science
Vol. 21, 20 December 2023
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From RNA world to RNA-peptide world: A review
* Author to whom correspondence should be addressed.
Abstract
How life starts from small molecules to RNAs and further to modern life is an unanswered question. Cyanosulfitic chemistry established the synthesis of building blocks, including 12 proteinogenic amino acids, 4 ribo- and deoxyribo-nucleosides, and phospholipids, from hydrogen cyanide and hydrogen sulfite under prebiotically plausible conditions. Later on, the non-enzymatic monomer extension of nucleotides provided a plausible pathway from mononucleotides to RNAs giving rise to the RNA world. RNA is one of the key components for the origin of life, firstly, the sequence information can be heritage by template copying reaction. Secondly, RNA is able to fold into a secondary structure which has the capability to catalyze chemical reactions. The RNA world scenario has perfectly overcome the chicken-egg problem, but it still cannot explain why peptides are involved in modern life. Most recently, with the establishment of the reaction between RNA and peptides, the trajectory to the RNA-peptide world theory has opened up a new era of the origin of life research. Here I will discuss the current results relevant to the RNA world to RNA-peptide world theory.
Keywords
RNA world, RNA-peptide world, the non-enzymatic replication of nucleotides.
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Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the 3rd International Conference on Biological Engineering and Medical Science
- ISBN (Print)
- 978-1-83558-215-2
- ISBN (Online)
- 978-1-83558-216-9
- Published Date
- 20 December 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/21/20230843
- Copyright
- 20 December 2023
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited