Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 15, 04 December 2023
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TREM2 mediated Aβ clearance dysfunction in microglia cells by circadian disruption in Alzheimer's disease
* Author to whom correspondence should be addressed.
Abstract
Genome-wide association studies (GWAS) have shown that the Trem2 gene is a risk factor associated with the onset of Alzheimer's Disease (AD). The Trem2 gene is highly expressed on the surface membrane of microglia cells in the central neuron system (CNS), which mediates neuron inflammation and the clearance of axons and synapses. As a growing amount of evidence is connecting Circadian disruptions with increased levels of CNS inflammation, this review aims to find a connection between circadian disruption and amyloid-leading Alzheimer’s disease through Trem2 in Microglia cells. This review summarizes past research independently about the circadian disruption with microglia activation, microglia activation with Trem2, and Trem2-affected MG cells impacting the development of Alzheimer’s Disease. Further research may focus on specifying the importance of Trem2 microglia cells caused neuron inflammation in the development of Alzheimer's pathology, for whether the early A-beta plaquing is triggered by Trem2 microglia cells, or Trem2 is just contributing but not the causation of AD in its Mild Cognitive impairment (MCI) stage.
Keywords
Circadian Disruption, Microglia, Trem2, Beta-Amyloid
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Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the 2nd International Conference on Modern Medicine and Global Health
- ISBN (Print)
- 978-1-83558-193-3
- ISBN (Online)
- 978-1-83558-194-0
- Published Date
- 04 December 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/15/20240465
- Copyright
- 04 December 2023
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited