Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 15, 04 December 2023
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Access | Article
Mechanisms of action of tea polyphenols in the modulation of obesity through gut microbiota
* Author to whom correspondence should be addressed.
Abstract
Obesity has become an increasingly serious global issue in recent years, leading to a myriad of health concerns for a growing population. Consequently, the quest for rational and safe methods to combat excess body fat has emerged as a mainstream demand among consumers. This paper focuses on tea polyphenols as the primary subject of investigation, employing gut microbiota as a mediator to explore and summarize existing research regarding the anti-obesity effects of tea polyphenols. Current reports suggest that the mechanisms by which tea polyphenols exhibit anti-obesity effects primarily encompass two aspects. Firstly, tea polyphenols can regulate the composition of the gut microbiota, primarily targeting the Firmicutes and Bacteroidetes phyla. This regulation occurs both in their digested state and undigested form, with a greater emphasis on their undigested state. Tea polyphenols primarily function by reducing the abundance of Firmicutes while increasing that of Bacteroidetes, thereby enhancing gut microbiota diversity to exert anti-obesity effects. Secondly, the metabolites of tea polyphenols also play a role in modulating gut microbiota, with phenolic acid compounds being the key metabolites responsible for anti-obesity effects. Compared to the parent tea polyphenols, phenolic acid compounds exhibit higher bioavailability and biological activity.
Keywords
Anti-Obesity, Tea Polyphenols, Gut Microbiota, Mechanisms
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Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the 2nd International Conference on Modern Medicine and Global Health
- ISBN (Print)
- 978-1-83558-193-3
- ISBN (Online)
- 978-1-83558-194-0
- Published Date
- 04 December 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/15/20240380
- Copyright
- 04 December 2023
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited