Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 22, 20 December 2023
Open
Access | Article
Research on genetic regulation of sleep
* Author to whom correspondence should be addressed.
Abstract
Sleep is the most vital function of mammals to maintain energy homeostasis. For years, the mechanism behind how sleep is regulated has been studied, and several genetic pathways had been identified as the key to encoding the circadian rhythms to enable the mammalian sleep and wake cycles. This paper explains the mechanisms behind the PER, CRY, CLOCK, and BMAL1 pathways, which play a central role in manipulating the function of the circadian clock. Other pathways, such as the DEC1/2 genes, interact with the circadian clock genes to form negative feedback loops to further control the circadian rhythm pathway and directly regulate sleep through orexin. Mutations occurring in these pathways could potentially cause conditions such as narcolepsy, restless leg syndrome, insomnia, sleep apnea, delayed sleep phase syndrome (DSPS), and advanced sleep phase syndrome (ASPS). These conclusions are based on previous studies and experiments that identified these pathways. While recent studies have shed light on the mechanisms of the PER, CLOCK, BMAL1, and DEC genes in regulating sleep and circadian rhythms, there is still much to discover. The intricate interactions and genetic pathways involved in sleep regulation are not yet fully understood. Further research in this field may uncover new insights into the genetic basis of sleep and provide avenues for developing interventions to address sleep disorders.
Keywords
genetic regulation, sleep disorders, circadian system
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Data Availability
The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.
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- Volume Title
- Proceedings of the 3rd International Conference on Biological Engineering and Medical Science
- ISBN (Print)
- 978-1-83558-217-6
- ISBN (Online)
- 978-1-83558-218-3
- Published Date
- 20 December 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/22/20230939
- Copyright
- 20 December 2023
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited