Theoretical and Natural Science
- The Open Access Proceedings Series for Conferences
Theoretical and Natural Science
Vol. 16, 04 December 2023
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Research progress in the treatment of acne
* Author to whom correspondence should be addressed.
Abstract
Acne is widely distributed globally, especially prevalent among adolescents and adults, and is one of the most common skin diseases clinically. Research has found that acne is a common chronic skin disease involving the sebaceous gland unit, and its pathogenesis involves multiple factors such as genetics and metabolism, including infection of Propionibacterium acnes, overactivation of sebaceous glands, abnormal follicular keratinization, and enhanced inflammatory response. Currently, topical drug therapy, systemic drug therapy, phototherapy, and chemical peel therapy have gained consensus in the treatment of acne. This review discusses the various advancements in acne treatment, including the use of probiotics as an adjuvant therapy based on the gut-skin axis and the latest research progress in biologic antibody-based immunotherapy targeting the pathophysiology of acne.
Keywords
Acne, Acne Treatment, Drug Therapy, Pathogenesis of Acne
References
1. Zaenglein AL, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016; 74(5): 945-973.
2. Del Rosso JQ, et al. Status Report from the Scientific Panel on Antibiotic Use in Dermatology of the American Acne and Rosacea Society Part 1: Antibiotic Prescribing Patterns, Sources of Antibiotic Exposure, Antibiotic Consumption and Emergence of Antibiotic Resistance, Impact of Alterations in Antibiotic Prescribing, and Clinical Sequelae of Antibiotic Use. The Journal of Clinical and Aesthetic Dermatology. 2020; 13(2): 16-24.
3. Eady EA, et al. Benzoyl peroxide cream (4%) in combination with erythromycin (3%) gel in the treatment of acne vulgaris: A randomized, double-blind, controlled study. The British Journal of Dermatology. 1997; 136(5): 699-702.
4. Strauss JS, et al. Topical erythromycin and zinc therapy for acne. Journal of the American Academy of Dermatology. 1988; 19(5 Pt 1): 852-856.
5. Del Rosso JQ, et al. Status Report from the Scientific Panel on Antibiotic Use in Dermatology of the American Acne and Rosacea Society Part 1: Antibiotic Prescribing Patterns, Sources of Antibiotic Exposure, Antibiotic Consumption and Emergence of Antibiotic Resistance, Impact of Alterations in Antibiotic Prescribing, and Clinical Sequelae of Antibiotic Use. The Journal of Clinical and Aesthetic Dermatology. 2020; 13(2): 16-24.
6. Pavicic T, et al. The role of topical quinolones in the management of acne. Journal of the European Academy of Dermatology and Venereology. 2005; 19(6): 672-677.
7. Thiboutot D, et al. Topical antimicrobial treatment of acne vulgaris: An evidence-based review. Am J Clin Dermatol. 2005; 6(4): 273-287.
8. Kubba R, et al. Topical benzoyl peroxide and erythromycin: effect on Propionibacterium acnes and free fatty acid composition. Br J Dermatol. 1986; 115(4): 417-421.
9. Mills OH Jr, et al. The effect of topical salicylic acid on the histologic structure of acne vulgaris. Journal of Investigative Dermatology. 1978; 71(2): 92-97.
10. Eady EA, et al. Benzoyl peroxide cream (4%) in combination with erythromycin (3%) gel in the treatment of acne vulgaris: A randomized, double-blind, controlled study. The British Journal of Dermatology. 1997; 136(5): 699-702.
11. Mukherjee S, et al. Retinoids in the treatment of skin aging: an overview of clinical efficacy and safety. Clin Interv Aging. 2006; 1(4): 327-348.
12. Leyden JJ, et al. Topical treatment of acne vulgaris: Retinoids and cutaneous irritation. J Am Acad Dermatol. 1986; 15(4 Pt 2): 880-885.
13. Kim J, et al. Investigation of anti-inflammatory and antinociceptive activities of Piper cubeba, Physalis angulata and Rosa hybrida. J Ethnopharmacol. 2007; 112(2): 394-400.
14. Orfanos CE, et al. Oral retinoids in the treatment of seborrhoea and acne. Dermatologica. 1978;157(4):238-52.
15. Leyden JJ, et al. Topical treatment of acne vulgaris: Retinoids and cutaneous irritation. J Am Acad Dermatol. 1986;15(4 Pt 2):880-5.
16. Epstein JH, et al. Effects of long-term, low-dose isotretinoin on sebaceous gland secretion and acne. Clin Pharmacol Ther. 1982; 31(2):209-17.
17. Del Rosso JQ, et al. Status Report from the Scientific Panel on Antibiotic Use in Dermatology of the American Acne and Rosacea Society Part 1: Antibiotic Prescribing Patterns, Sources of Antibiotic Exposure, Antibiotic Consumption and Emergence of Antibiotic Resistance, Impact of Alterations in Antibiotic Prescribing, and Clinical Sequelae of Antibiotic Use. The Journal of Clinical and Aesthetic Dermatology. 2020; 13(2): 16-24.
18. Mills OH Jr, et al. Effects of topical benzoyl peroxide on the free fatty acid composition of surface lipids in acne vulgaris. J Invest Dermatol. 1983; 81(4): 275-278.
19. Zaenglein AL, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016; 74(5): 945-973.
20. Eady EA, et al. Propionibacterium acnes resistance: a worldwide problem. Dermatology. 2003; 206(1): 54-56.
21. Mills OH Jr, et al. Safety and effectiveness of a 3% erythromycin and 5% benzoyl peroxide topical formulation for the treatment of acne vulgaris. J Am Acad Dermatol. 2002; 46(6): 917-922.
22. Leyden JJ, et al. Topical treatment of acne vulgaris: Retinoids and cutaneous irritation. J Am Acad Dermatol. 1986; 15(4 Pt 2): 880-885.
23. Mills OH Jr, et al. The effect of topical salicylic acid on the histologic structure of acne vulgaris. Journal of Investigative Dermatology. 1978; 71(2): 92-97.
24. Eichenfield LF, et al. Evidence-based recommendations for the diagnosis and treatment of pediatric acne. Pediatrics. 2013; 131(Suppl 3): S163-S186.
25. Thielitz A, et al. Topical retinoids in acne vulgaris: update on efficacy and safety. Am J Clin Dermatol. 2008; 9(6): 369-381.
26. Koo EB, et al. Hormonal therapy for acne: why not as first line therapy? facts and controversies. Clin Dermatol. 2010; 28(1): 17-23.
27. Zaenglein AL, et al. Guidelines of care for the management of acne vulgaris. J Am Acad Dermatol. 2016; 74(5): 945-973.
28. Del Rosso JQ, et al. Status Report from the Scientific Panel on Antibiotic Use in Dermatology of the American Acne and Rosacea Society Part 1: Antibiotic Prescribing Patterns, Sources of Antibiotic Exposure, Antibiotic Consumption and Emergence of Antibiotic Resistance, Impact of Alterations in Antibiotic Prescribing, and Clinical Sequelae of Antibiotic Use. The Journal of Clinical and Aesthetic Dermatology. 2020; 13(2): 16-24.
29. Thiboutot D, et al. New insights into the management of acne: an update from the Global Alliance to Improve Outcomes in Acne Group. Journal of the American Academy of Dermatology. 2009; 60(5 Suppl): S1-S50.
30. Nast A, et al. European evidence-based (S3) guidelines for the treatment of acne. Journal of the European Academy of Dermatology and Venereology. 2012; 26(Suppl 1): 1-29.
31. Lucky AW, et al. Hormonal therapy for acne: why not as first line therapy? facts and controversies. J Drugs Dermatol. 2013; 12(5): 535-540.
32. Lee SY, et al. Clinical and Histological Effect of a Low-Fluence Q-Switched 1064-nm Neodymium-Doped Yttrium-Aluminum-Garnet Laser for the Treatment of Inflammatory Acne. Dermatologic Surgery. 2019; 45(3): 429-436.
33. Papageorgiou P, et al. Phototherapy with blue (415 nm) and red (660 nm) light in the treatment of acne vulgaris. Br J Dermatol. 2000; 142(5): 973-978.
34. Dreno B, et al. Light therapies in acne treatment. J Eur Acad Dermatol Venereol. 2015; 29 Suppl 5: 18-28.
35. Gittings P, et al. Laser and Light Treatments for Acne Rosacea. Dermatologic Clinics. 2021; 39(4): 555-563.
36. Alster TS, et al. Improvement of Striae with a Novel 1410-nm Fractional Photothermolysis Laser. Dermatologic Surgery. 2009; 35(11): 1585-1590.
37. Thiboutot D, et al. Adapalene-benzoyl peroxide, a fixed-dose combination for the treatment of acne vulgaris: Results of a multicenter, randomized double-blind, controlled study. Journal of the American Academy of Dermatology. 2007; 57(5): 791-799.
38. Chapas AM, et al. Successful Treatment of Acneiform Scarring with CO2 Ablative Fractional Resurfacing. Lasers in Surgery and Medicine. 2012; 44(2): 139-146.
39. Chan HH, et al. The use of non-ablative fractional resurfacing in Asian acne scar patients. Lasers in Surgery and Medicine. 2010; 42(10): 710-715.
40. Hantash BM, et al. Fractional photothermolysis: A novel aesthetic laser surgery modality. Dermatologic Surgery. 2007; 33(5): 525-534.
41. Gold MH, et al. A phase 2, multicenter, double-blind, randomized, vehicle controlled clinical study to assess the safety and efficacy of a halobetasol propionate 0.01% lotion in the treatment of plaque psoriasis. J Drugs Dermatol. 2018; 17(12): 1464-1471.
42. Kluk J, et al. Photodynamic therapy for acne vulgaris: a critical review from basics to clinical practice: part I. Understanding mechanisms of action, basic principles and molecular effects. J Eur Acad Dermatol Venereol. 2012; 26(8): 995-1005.
43. Wiegell SR, et al. Photodynamic therapy for acne vulgaris: a randomized, controlled, split-face clinical trial of topical aminolevulinic acid and red light in comparison with topical erythromycin cream. Acta Derm Venereol. 2006; 86(5): 428-432.
44. Fabbrocini G, et al. Chemical peels for acne and acne scars in Asians: Evidence based review. J Cutan Aesthet Surg. 2010; 3(1): 49-55.
45. Briden E, et al. Chemical peels in the treatment of acne: patient selection and perspectives. Clin Cosmet Investig Dermatol. 2018; 11: 365-372.
46. Soleymani T, et al. A practical approach to chemical peels: a review of fundamentals and step-by-step algorithmic protocol for treatment. J Clin Aesthet Dermatol. 2018; 11(8): 21-28.
47. De Pessemier, B.; Grine, L.; Debaere, M.; Maes, A.; Paetzold, B.; Callewaert, C. Gut-Skin Axis: Current Knowledge of the Interrelationship between Microbial Dysbiosis and Skin Conditions. Microorganisms 2021, 9, 353
48. Yan HM, et al. Efficacy of Lactobacillus-containing probiotics in prevention of mild to moderate acne vulgaris: a randomized, double-blind, controlled trial. Dermatology and Therapy. 2020; 10(5): 989-1001.
49. Bowe WP, et al. Acne vulgaris, probiotics and the gut-brain-skin axis: from anecdote to translational medicine. Benef Microbes. 2014; 5(2): 185-199.
50. SÁNCHEZ-PELLICER P, NAVARRO-MORATALLA L, NÚÑEZ-DELEGIDO E, 等. Acne, Microbiome, and Probiotics: The Gut-Skin Axis[J/OL]. Microorganisms, 2022, 10(7): 1303.
51. Kurokawa I, Danby FW, Ju Q, et al. New developments in our understanding of acne pathogenesis and treatment. Exp Dermatol. 2009; 18(10):821-832
52. Kelhälä H-L, Palatsi R, Fyhrquist N, et al. IL-17/Th17 pathway is activated in acne lesions. PLoS One. 2014;9(8):e105238
53. Lapteva M, et al. Microencapsulation in the Treatment of Acne Vulgaris. Drug Delivery. 2015;22(6):753-758.
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- Volume Title
- Proceedings of the 2nd International Conference on Modern Medicine and Global Health
- ISBN (Print)
- 978-1-83558-195-7
- ISBN (Online)
- 978-1-83558-196-4
- Published Date
- 04 December 2023
- Series
- Theoretical and Natural Science
- ISSN (Print)
- 2753-8818
- ISSN (Online)
- 2753-8826
- DOI
- 10.54254/2753-8818/16/20240508
- Copyright
- 04 December 2023
- Open Access
- This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited