Theoretical and Natural Science

- The Open Access Proceedings Series for Conferences


Theoretical and Natural Science

Vol. 33, 08 March 2024


Open Access | Article

The effect of Omega-3 fatty acid– fish oil and seed oil–on the prevention of Alzheimer’s disease

Huaqing Li * 1 , Yueran Pan 2
1 University of Wisconsin Madison
2 University of Wisconsin Madison

* Author to whom correspondence should be addressed.

Theoretical and Natural Science, Vol. 33, 12-19
Published 08 March 2024. © 2023 The Author(s). Published by EWA Publishing
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Citation Huaqing Li, Yueran Pan. The effect of Omega-3 fatty acid– fish oil and seed oil–on the prevention of Alzheimer’s disease. TNS (2024) Vol. 33: 12-19. DOI: 10.54254/2753-8818/33/20240534.

Abstract

Omega-3 polyunsaturated fatty acids (n-3 PUFA) are known to reduce cognitive degeneration and potentially prevent Alzheimer’s disease (AD). Unfortunately, while preventive measures like dietary therapy exist, there are few approved clinical healing therapies for AD. This study aims to investigate the effects of seed oil and fish oil separately in preventing Alzheimer’s disease. We conducted a systematic literature search to find experimental trials based on animal models and human observational studies examining the relationship between Alzheimer’s disease and oil supplements rich in n-3 PUFA. The study uses meta-analysis, t-tests, and regression analysis to determine the significance of each type of oil in regulating Alzheimer’s disease’s development. The results suggest that seed oil may help prevent AD by slowing cognitive deterioration, whereas fish oil may not. Overall, omega-3 fatty acids may serve as potential dietary supplements for improving memory and preventing Alzheimer’s disease.

Keywords

Alzheimer’s disease, Omega-3 fatty acid, seed oil, fish oil, cognitive ability

References

1. Uauy R, Hoffman DR, Peirano P, Birch DG, Birch EE (2001), Essential fatty acids in visual and brain development. Lipids, 36, 885-895. -DOI:0.1007/s11745-001-0798-1

2. Hashimoto M, Hossain S, Shimada T, Sugioka K, Yamasaki H, Fujii Y, Ishibashi Y, Oka JI, Shido O (2002) Docosahexaenoic acid provides protection from impairment of learning ability in Alzheimer’s disease model rats. J Neurochem 81, 1084-1091.

3. Pawlosky RJ, Hibbeln JR, Novotny JA, Salem NJ. Physiological com- partmental analysis of alpha-linolenic acid metabolism in adult humans. J Lipid Res 2001; 42:1257–1265. PMID: 11483627.

4. Wei, G., Zhang, Z., Fu, D., Zhang, Y., Zhang, W., Zu, Y., Zhang, L., & Zhang, Z. (2021). Enzyme-assisted Solvent Extraction of High-yield Paeonia suffruticosa Andr. Seed Oil and Fatty Acid Composition and Anti-Alzheimer’s Disease Activity. Journal of Oleo Science, 70(8), 1133–1146. https://doi.org/10.5650/jos.ess21040

5. Takeyama, E., Islam, A., Watanabe, N., Tsubaki, H., Fukushima, M., Mamun, M. A., Sato, S., Sato, T., Eto, F., Yao, I., Ito, T. K., Horikawa, M., & Setou, M. (2019). Dietary Intake of Green Nut Oil or DHA Ameliorates DHA Distribution in the Brain of a Mouse Model of Dementia Accompanied by Memory Recovery. Nutrients, 11(10), 2371. https://doi.org/10.3390/ nu11102371

6. Gao, J., Wang, L., Zhao, C., Wu, Y., Lu, Z., Gu, Y., Ba, Z., Wang, X., Wang, J., & Xu, Y. (2021). Peony seed oil ameliorates neuroinflammation-mediated cognitive deficits by suppressing microglial activation through inhibition of NF-κB pathway in presenilin 1/2 conditional double knockout mice. Journal of Leukocyte Biology, 110(6), 1005–1022. https://doi.org/10.1002/JLB.3MA0821-639RR

7. Calder, P. C. (2017). Very long-chain n-3 fatty acids and human health: Fact, fiction and the future. Proceedings of the Nutrition Society, 77(1), 52–72. https://doi.org/10.1017/s0029665117003950

8. Witte AV, Kerti L, Hermannstädter HM, Fiebach JB, Schreiber SJ, Schuchardt JP, Hahn A, Flöel A. Long-chain omega-3 fatty acids improve brain function and structure in older adults. Cereb Cortex. 2014 Nov;24(11):3059-68. doi: 10.1093/cercor/bht163. Epub 2013 Jun 24. PMID: 23796946

9. Folstein, M. F., Folstein, S. E., & McHugh, P. R. (1975). “mini-mental state.” Journal of Psychiatric Research, 12(3), 189–198. https://doi.org/10.1016/0022-3956(75)90026-6

10. Abubakari, A. R., Naderali, M. M., & Naderali, E. K. (2014). Omega-3 fatty acid supplementation and cognitive function: are smaller dosages more beneficial?. International journal of general medicine, 7, 463–473. https://doi.org/10.2147/IJGM.S67065

11. Yurko-Mauro K, Alexander DD, Van Elswyk ME (2015) Docosahexaenoic Acid and Adult Memory: A Systematic Review and Meta-Analysis. PLOS ONE 10(3): e0120391. https://doi.org/10.1371/journal.pone.0120391

12. Kröger, E., Verreault, R., Carmichael, P.-H., Lindsay, J., Julien, P., Dewailly, É., Ayotte, P., & Laurin, D. (2009). Omega-3 fatty acids and risk of dementia: The Canadian Study of Health and Aging. The American Journal of Clinical Nutrition, 90(1), 184–192. https://doi.org/10.3945/ajcn.2008.26987

13. Barberger-Gateau, P. (2002). Fish, meat, and risk of dementia: Cohort study. BMJ, 325(7370), 932–933. https://doi.org/10.1136/bmj.325.7370.932

14. Morris, M. C., Evans, D. A., Bienias, J. L., Tangney, C. C., Bennett, D. A., Wilson, R. S., Aggarwal, N., & Schneider, J. (2003). Consumption of fish and N-3 fatty acids and risk of incident alzheimer disease. Archives of Neurology, 60(7), 940. https://doi.org/10.1001/archneur.60.7.940

Data Availability

The datasets used and/or analyzed during the current study will be available from the authors upon reasonable request.

This work is licensed under a Creative Commons Attribution-ShareAlike 4.0 International License. Authors who publish this series agree to the following terms:

1. Authors retain copyright and grant the series right of first publication with the work simultaneously licensed under a Creative Commons Attribution License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this series.

2. Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the series's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in this series.

3. Authors are permitted and encouraged to post their work online (e.g., in institutional repositories or on their website) prior to and during the submission process, as it can lead to productive exchanges, as well as earlier and greater citation of published work (See Open Access Instruction).

Volume Title
Proceedings of the 2nd International Conference on Modern Medicine and Global Health
ISBN (Print)
978-1-83558-323-4
ISBN (Online)
978-1-83558-324-1
Published Date
08 March 2024
Series
Theoretical and Natural Science
ISSN (Print)
2753-8818
ISSN (Online)
2753-8826
DOI
10.54254/2753-8818/33/20240534
Copyright
08 March 2024
Open Access
This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited

Copyright © 2023 EWA Publishing. Unless Otherwise Stated